CD16 cross-linking blocks rearrangement of the TCRβ locus and development of αβ T cells and induces development of NK cells from thymic progenitors

Scott K. Durum, Chong Kil Lee, Theresa M. Geiman, William J Murphy, Kathrin Muegge

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Mouse thymocytes normally develop into T lymphocytes, but the embryonic thymus also contains precursor cells capable of developing into NK cells. Here, we describe conditions that induce pro-T cells to develop into NK cells. CD16 is expressed on thymic pro-T cells. We observed that CD16 cross- linking during culture of embryonic thymic organs suppressed rearrangement of the TCRβ locus (but did not inhibit TCRγ locus rearrangement). Rearrangement of the TCRβ locus is normally required for development to the CD4+CD8+, and this development was also suppressed by CD16 cross-linking. The ability of CD16 cross-linking to block αβT cell development was not attributable to toxic effects, but rather was accompanied by promotion of development into NK cells, identified based on molecular and functional criteria. These results suggest that common lymphoid precursors can respond to environmental signals to commit to the αβT vs NK developmental pathways.

Original languageEnglish (US)
Pages (from-to)3325-3329
Number of pages5
JournalJournal of Immunology
Volume161
Issue number7
StatePublished - Oct 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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