CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

Rosa Maria Salazar-Gonzalez, Jan H. Niess, David J. Zammit, Rajesh Ravindran, Aparna Srinivasan, Joseph R. Maxwell, Thomas Stoklasek, Rajwardhan Yadav, Ifor R. Williams, Xiubin Gu, Beth A. McCormick, Michael A. Pazos, Anthony T. Vella, Leo Lefrancois, Hans Christian Reinecker, Stephen J Mcsorley

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

T cell activation by dendritic cells (DCs) is critical to the initiation of adaptive immune responses and protection against pathogens. Here, we demonstrate that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells. This DC subset is characterized by the expression of the chemokine receptor CCR6 and is found only in PPs. CCR6+ DCs were recruited into the dome regions of PPs upon invasion of the follicle associated epithelium (FAE) by an enteric pathogen and were responsible for the rapid local activation of pathogen-specific T cells. CCR6-deficient DCs were unable to respond to bacterial invasion of PPs and failed to initiate T cell activation, resulting in reduced defense against oral infection. Thus, CCR6-dependent regulation of DCs is responsible for localized T cell dependent defense against entero-invasive pathogens.

Original languageEnglish (US)
Pages (from-to)623-632
Number of pages10
JournalImmunity
Volume24
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Peyer's Patches
Dendritic Cells
T-Lymphocytes
Chemokine Receptors
Adaptive Immunity
Epithelium
Infection

Keywords

  • CELLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Salazar-Gonzalez, R. M., Niess, J. H., Zammit, D. J., Ravindran, R., Srinivasan, A., Maxwell, J. R., ... Mcsorley, S. J. (2006). CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches. Immunity, 24(5), 623-632. https://doi.org/10.1016/j.immuni.2006.02.015

CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches. / Salazar-Gonzalez, Rosa Maria; Niess, Jan H.; Zammit, David J.; Ravindran, Rajesh; Srinivasan, Aparna; Maxwell, Joseph R.; Stoklasek, Thomas; Yadav, Rajwardhan; Williams, Ifor R.; Gu, Xiubin; McCormick, Beth A.; Pazos, Michael A.; Vella, Anthony T.; Lefrancois, Leo; Reinecker, Hans Christian; Mcsorley, Stephen J.

In: Immunity, Vol. 24, No. 5, 05.2006, p. 623-632.

Research output: Contribution to journalArticle

Salazar-Gonzalez, RM, Niess, JH, Zammit, DJ, Ravindran, R, Srinivasan, A, Maxwell, JR, Stoklasek, T, Yadav, R, Williams, IR, Gu, X, McCormick, BA, Pazos, MA, Vella, AT, Lefrancois, L, Reinecker, HC & Mcsorley, SJ 2006, 'CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches', Immunity, vol. 24, no. 5, pp. 623-632. https://doi.org/10.1016/j.immuni.2006.02.015
Salazar-Gonzalez RM, Niess JH, Zammit DJ, Ravindran R, Srinivasan A, Maxwell JR et al. CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches. Immunity. 2006 May;24(5):623-632. https://doi.org/10.1016/j.immuni.2006.02.015
Salazar-Gonzalez, Rosa Maria ; Niess, Jan H. ; Zammit, David J. ; Ravindran, Rajesh ; Srinivasan, Aparna ; Maxwell, Joseph R. ; Stoklasek, Thomas ; Yadav, Rajwardhan ; Williams, Ifor R. ; Gu, Xiubin ; McCormick, Beth A. ; Pazos, Michael A. ; Vella, Anthony T. ; Lefrancois, Leo ; Reinecker, Hans Christian ; Mcsorley, Stephen J. / CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches. In: Immunity. 2006 ; Vol. 24, No. 5. pp. 623-632.
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AU - Pazos, Michael A.

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