CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection

Rajesh Ravindran, Lori Rusch, Andrea Itano, Marc K. Jenkins, Stephen J Mcsorley

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent. In marked contrast the tempo of pathogen-specific CD4 T cell activation depended on whether the antigen was secreted or cell-associated. Furthermore, lymph node pathogen-specific CD4 T cell activation required CCR6 and cell migration from the site of infection. Surprisingly, adoptive transfer of wild-type blood phagocytes rescued bacteria-specific T cell activation in CCR6-deficient mice, even when these cells were unable to participate in direct antigen presentation. These data demonstrate that T cell responses to a local bacterial infection follow a distinct tempo, largely determined by bacterial protein secretion, and that CCR6-mediated blood phagocyte recruitment to the site of infection is a critical step in the initiation of pathogen-specific immune responses in skin draining lymph nodes.

Original languageEnglish (US)
Pages (from-to)12075-12080
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number29
DOIs
StatePublished - Jul 17 2007
Externally publishedYes

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Phagocytes
Bacterial Infections
T-Lymphocytes
Lymph Nodes
Antigens
Bacterial Proteins
Adoptive Transfer
Antigen Presentation
Infection
Cell Movement
Bacteria
Skin

Keywords

  • Antigen presentation
  • Bacteria

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection. / Ravindran, Rajesh; Rusch, Lori; Itano, Andrea; Jenkins, Marc K.; Mcsorley, Stephen J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 29, 17.07.2007, p. 12075-12080.

Research output: Contribution to journalArticle

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