CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status

Trevor L. Hoffman, Rob Roy MacGregor, Harold Burger, Rosemarie Mick, Robert W. Doms, Ronald G. Collman

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Persons who are homozygous for the Δ32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1- discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the Δ32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the Δ32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons who are most likely to carry the Δ32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV- 1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous Δ32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.

Original languageEnglish (US)
Pages (from-to)1093-1096
Number of pages4
JournalJournal of Infectious Diseases
Volume176
Issue number4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Hoffman, T. L., MacGregor, R. R., Burger, H., Mick, R., Doms, R. W., & Collman, R. G. (1997). CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. Journal of Infectious Diseases, 176(4), 1093-1096.