Abstract
Persons who are homozygous for the Δ32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1- discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the Δ32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the Δ32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons who are most likely to carry the Δ32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV- 1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous Δ32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.
Original language | English (US) |
---|---|
Pages (from-to) | 1093-1096 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 176 |
Issue number | 4 |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology