Abstract
Persons who are homozygous for the Δ32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1- discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the Δ32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the Δ32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons who are most likely to carry the Δ32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV- 1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous Δ32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1093-1096 |
| Number of pages | 4 |
| Journal | Journal of Infectious Diseases |
| Volume | 176 |
| Issue number | 4 |
| State | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. / Hoffman, Trevor L.; MacGregor, Rob Roy; Burger, Harold; Mick, Rosemarie; Doms, Robert W.; Collman, Ronald G.
In: Journal of Infectious Diseases, Vol. 176, No. 4, 1997, p. 1093-1096.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status
AU - Hoffman, Trevor L.
AU - MacGregor, Rob Roy
AU - Burger, Harold
AU - Mick, Rosemarie
AU - Doms, Robert W.
AU - Collman, Ronald G.
PY - 1997
Y1 - 1997
N2 - Persons who are homozygous for the Δ32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1- discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the Δ32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the Δ32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons who are most likely to carry the Δ32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV- 1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous Δ32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.
AB - Persons who are homozygous for the Δ32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1- discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the Δ32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the Δ32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons who are most likely to carry the Δ32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV- 1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous Δ32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.
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M3 - Article
C2 - 9333175
AN - SCOPUS:0030798652
VL - 176
SP - 1093
EP - 1096
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -