CCK1 receptor is essential for normal meal patterning in mice fed high fat diet

Michael J. Donovan, Gabriel Paulino, Helen E Raybould

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cholecystokinin (CCK), released by lipid in the intestine, initiates satiety by acting at cholecystokinin type 1 receptors (CCK1Rs) located on vagal afferent nerve terminals located in the wall of the gastrointestinal tract. In the present study, we determined the role of the CCK1R in the short term effects of a high fat diet on daily food intake and meal patterns using mice in which the CCK1R gene is deleted. CCK1R-/- and CCK1R+/+ mice were fed isocaloric high fat (HF) or low fat (LF) diets ad libitum for 18 h each day and meal size, meal frequency, intermeal interval, and meal duration were determined. Daily food intake was unaltered by diet in the CCK1R-/- compared to CCK1R+/+ mice. However, meal size was larger in the CCK1R-/- mice compared to CCK1R+/+ mice when fed a HF diet, with a concomitant decrease in meal frequency. Meal duration was increased in mice fed HF diet regardless of phenotype. In addition, CCK1R-/- mice fed a HF diet had a 75% decrease in the time to 1st meal compared to CCK1R+/+ mice following a 6 h fast. These data suggest that lack of the CCK1R results in diminished satiation, causing altered meal patterns including larger, less frequent meals when fed a high fat diet. These results suggest that the CCK1R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake.

Original languageEnglish (US)
Pages (from-to)969-974
Number of pages6
JournalPhysiology and Behavior
Volume92
Issue number5
DOIs
StatePublished - Dec 5 2007

Fingerprint

High Fat Diet
Meals
Cholecystokinin Receptors
Eating
Satiation
Appetite Regulation
Fat-Restricted Diet
Cholecystokinin
Energy Intake
Intestines
Gastrointestinal Tract
Mouse Ccl28 protein
Fats
Diet
Phenotype
Lipids

Keywords

  • Cholecystokinin type 1 receptor
  • High fat diet
  • Meal pattern analysis

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

CCK1 receptor is essential for normal meal patterning in mice fed high fat diet. / Donovan, Michael J.; Paulino, Gabriel; Raybould, Helen E.

In: Physiology and Behavior, Vol. 92, No. 5, 05.12.2007, p. 969-974.

Research output: Contribution to journalArticle

Donovan, Michael J. ; Paulino, Gabriel ; Raybould, Helen E. / CCK1 receptor is essential for normal meal patterning in mice fed high fat diet. In: Physiology and Behavior. 2007 ; Vol. 92, No. 5. pp. 969-974.
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