Abstract
Cholecystokinin (CCK), released by lipid in the intestine, initiates satiety by acting at cholecystokinin type 1 receptors (CCK1Rs) located on vagal afferent nerve terminals located in the wall of the gastrointestinal tract. In the present study, we determined the role of the CCK1R in the short term effects of a high fat diet on daily food intake and meal patterns using mice in which the CCK1R gene is deleted. CCK1R-/- and CCK1R+/+ mice were fed isocaloric high fat (HF) or low fat (LF) diets ad libitum for 18 h each day and meal size, meal frequency, intermeal interval, and meal duration were determined. Daily food intake was unaltered by diet in the CCK1R-/- compared to CCK1R+/+ mice. However, meal size was larger in the CCK1R-/- mice compared to CCK1R+/+ mice when fed a HF diet, with a concomitant decrease in meal frequency. Meal duration was increased in mice fed HF diet regardless of phenotype. In addition, CCK1R-/- mice fed a HF diet had a 75% decrease in the time to 1st meal compared to CCK1R+/+ mice following a 6 h fast. These data suggest that lack of the CCK1R results in diminished satiation, causing altered meal patterns including larger, less frequent meals when fed a high fat diet. These results suggest that the CCK1R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 969-974 |
| Number of pages | 6 |
| Journal | Physiology and Behavior |
| Volume | 92 |
| Issue number | 5 |
| DOIs | |
| State | Published - Dec 5 2007 |
Fingerprint
Keywords
- Cholecystokinin type 1 receptor
- High fat diet
- Meal pattern analysis
ASJC Scopus subject areas
- Behavioral Neuroscience
- Physiology (medical)
Cite this
CCK1 receptor is essential for normal meal patterning in mice fed high fat diet. / Donovan, Michael J.; Paulino, Gabriel; Raybould, Helen E.
In: Physiology and Behavior, Vol. 92, No. 5, 05.12.2007, p. 969-974.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CCK1 receptor is essential for normal meal patterning in mice fed high fat diet
AU - Donovan, Michael J.
AU - Paulino, Gabriel
AU - Raybould, Helen E
PY - 2007/12/5
Y1 - 2007/12/5
N2 - Cholecystokinin (CCK), released by lipid in the intestine, initiates satiety by acting at cholecystokinin type 1 receptors (CCK1Rs) located on vagal afferent nerve terminals located in the wall of the gastrointestinal tract. In the present study, we determined the role of the CCK1R in the short term effects of a high fat diet on daily food intake and meal patterns using mice in which the CCK1R gene is deleted. CCK1R-/- and CCK1R+/+ mice were fed isocaloric high fat (HF) or low fat (LF) diets ad libitum for 18 h each day and meal size, meal frequency, intermeal interval, and meal duration were determined. Daily food intake was unaltered by diet in the CCK1R-/- compared to CCK1R+/+ mice. However, meal size was larger in the CCK1R-/- mice compared to CCK1R+/+ mice when fed a HF diet, with a concomitant decrease in meal frequency. Meal duration was increased in mice fed HF diet regardless of phenotype. In addition, CCK1R-/- mice fed a HF diet had a 75% decrease in the time to 1st meal compared to CCK1R+/+ mice following a 6 h fast. These data suggest that lack of the CCK1R results in diminished satiation, causing altered meal patterns including larger, less frequent meals when fed a high fat diet. These results suggest that the CCK1R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake.
AB - Cholecystokinin (CCK), released by lipid in the intestine, initiates satiety by acting at cholecystokinin type 1 receptors (CCK1Rs) located on vagal afferent nerve terminals located in the wall of the gastrointestinal tract. In the present study, we determined the role of the CCK1R in the short term effects of a high fat diet on daily food intake and meal patterns using mice in which the CCK1R gene is deleted. CCK1R-/- and CCK1R+/+ mice were fed isocaloric high fat (HF) or low fat (LF) diets ad libitum for 18 h each day and meal size, meal frequency, intermeal interval, and meal duration were determined. Daily food intake was unaltered by diet in the CCK1R-/- compared to CCK1R+/+ mice. However, meal size was larger in the CCK1R-/- mice compared to CCK1R+/+ mice when fed a HF diet, with a concomitant decrease in meal frequency. Meal duration was increased in mice fed HF diet regardless of phenotype. In addition, CCK1R-/- mice fed a HF diet had a 75% decrease in the time to 1st meal compared to CCK1R+/+ mice following a 6 h fast. These data suggest that lack of the CCK1R results in diminished satiation, causing altered meal patterns including larger, less frequent meals when fed a high fat diet. These results suggest that the CCK1R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake.
KW - Cholecystokinin type 1 receptor
KW - High fat diet
KW - Meal pattern analysis
UR - http://www.scopus.com/inward/record.url?scp=36048968171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048968171&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2007.07.003
DO - 10.1016/j.physbeh.2007.07.003
M3 - Article
C2 - 18023701
AN - SCOPUS:36048968171
VL - 92
SP - 969
EP - 974
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 5
ER -