Abstract
CCK-58 and has been shown to be the major circulating form of the hormone in the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokinin bioactivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1307-1311 |
| Number of pages | 5 |
| Journal | Peptides |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| State | Published - 1996 |
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Keywords
- Bioactivity
- CCK-58
- Cholecystokinin
- Gastric motility
- Pancreas
- Pancreatic secretion
- Structure-function
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
CCK-58 : A novel reagent for studying the regulation of cholecystokinin bioactivity. / Raybould, Helen E; Reeve, Joseph R.
In: Peptides, Vol. 17, No. 8, 1996, p. 1307-1311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CCK-58
T2 - A novel reagent for studying the regulation of cholecystokinin bioactivity
AU - Raybould, Helen E
AU - Reeve, Joseph R.
PY - 1996
Y1 - 1996
N2 - CCK-58 and has been shown to be the major circulating form of the hormone in the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokinin bioactivity.
AB - CCK-58 and has been shown to be the major circulating form of the hormone in the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokinin bioactivity.
KW - Bioactivity
KW - CCK-58
KW - Cholecystokinin
KW - Gastric motility
KW - Pancreas
KW - Pancreatic secretion
KW - Structure-function
UR - http://www.scopus.com/inward/record.url?scp=0030457952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030457952&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(96)00200-8
DO - 10.1016/S0196-9781(96)00200-8
M3 - Article
C2 - 8971924
AN - SCOPUS:0030457952
VL - 17
SP - 1307
EP - 1311
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 8
ER -