CCK-58: A novel reagent for studying the regulation of cholecystokinin bioactivity

Helen E Raybould, Joseph R. Reeve

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

CCK-58 and has been shown to be the major circulating form of the hormone in the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokinin bioactivity.

Original languageEnglish (US)
Pages (from-to)1307-1311
Number of pages5
JournalPeptides
Volume17
Issue number8
DOIs
StatePublished - 1996

Keywords

  • Bioactivity
  • CCK-58
  • Cholecystokinin
  • Gastric motility
  • Pancreas
  • Pancreatic secretion
  • Structure-function

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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