Causal contribution and dynamical encoding in the striatum during evidence accumulation

Michael M. Yartsev, Timothy Hanks, Alice Misun Yoon, Carlos D. Brody

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.

Original languageEnglish (US)
Article numbere34929
JournaleLife
Volume7
DOIs
StatePublished - Aug 24 2018

Fingerprint

Decision Making
Decision making
Optogenetics
Parietal Lobe
Rodentia
Brain
Pharmacology
Networks (circuits)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Causal contribution and dynamical encoding in the striatum during evidence accumulation. / Yartsev, Michael M.; Hanks, Timothy; Yoon, Alice Misun; Brody, Carlos D.

In: eLife, Vol. 7, e34929, 24.08.2018.

Research output: Contribution to journalArticle

Yartsev, Michael M. ; Hanks, Timothy ; Yoon, Alice Misun ; Brody, Carlos D. / Causal contribution and dynamical encoding in the striatum during evidence accumulation. In: eLife. 2018 ; Vol. 7.
@article{cc978eb4022b4ae98f82ac7677e00477,
title = "Causal contribution and dynamical encoding in the striatum during evidence accumulation",
abstract = "A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.",
author = "Yartsev, {Michael M.} and Timothy Hanks and Yoon, {Alice Misun} and Brody, {Carlos D.}",
year = "2018",
month = "8",
day = "24",
doi = "10.7554/eLife.34929",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Causal contribution and dynamical encoding in the striatum during evidence accumulation

AU - Yartsev, Michael M.

AU - Hanks, Timothy

AU - Yoon, Alice Misun

AU - Brody, Carlos D.

PY - 2018/8/24

Y1 - 2018/8/24

N2 - A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.

AB - A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.

UR - http://www.scopus.com/inward/record.url?scp=85053938405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053938405&partnerID=8YFLogxK

U2 - 10.7554/eLife.34929

DO - 10.7554/eLife.34929

M3 - Article

C2 - 30141773

AN - SCOPUS:85053938405

VL - 7

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e34929

ER -