Abstract
Cats require more dietary protein than noncarnivorous species. Earlier work showed that cats lack the ability to regulate hepatic urea cycle enzymes in response to dietary protein concentration. We thus hypothesized that cats are unable to fully adapt protein oxidation to protein intake, particularly at low-protein concentrations. We used indirect respiration calorimetry to assess cats' ability to adapt substrate oxidation to diets containing different concentrations of protein, including 1 below their protein requirement. Nine cats (5 males and 4 females; 2.7 ± 0.5 y; 4.49 ± 0.19 kg) consumed each of 4 semipurified diets containing 7.5% [low protein (LP3)], 14.2% [adequate protein (AP)], 27.1% [moderate protein (MP)], and 49.6% [high protein (HP)] of metabolizable energy from protein in a modified crossover design, beginning with the MP diet and then consuming the remaining diets in random order. After adaptation to each diet, cats completed a 5-d nitrogen balance trial and at least 2 12-h indirect calorimetry measurements. There was a significant effect of diet on protein oxidation (P < 0.0001), which measured 10.4 ± 0.5, 14.1 ± 1.0, 25.0 ± 1.7, and 53.2 ± 1.7% of total energy expenditure for the LP, AP, M,P and HP diets, respectively. The ratio of protein oxidation:protein intake was higher with the LP diet (1.39 ± 0.07) than the other 3 diets (AP, 1.00 ± 0.07; MP, 0.93 ± 0.06; HP, 1.07 ± 0.03; P < 0.0001), indicating a net loss of protein with the LP diet. Thus, cats are able to adapt protein oxidation to a wide range of dietary protein concentrations, provided their minimum protein requirement is met.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1053-1060 |
| Number of pages | 8 |
| Journal | Journal of Nutrition |
| Volume | 138 |
| Issue number | 6 |
| State | Published - Jun 2008 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
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Cats are able to adapt protein oxidation to protein intake provided their requirement for dietary protein is met. / Green, Alice S.; Ramsey, Jon J; Villaverde, Cecilia; Asami, Danny K.; Wei, Alfreda; Fascetti, Andrea J.
In: Journal of Nutrition, Vol. 138, No. 6, 06.2008, p. 1053-1060.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cats are able to adapt protein oxidation to protein intake provided their requirement for dietary protein is met
AU - Green, Alice S.
AU - Ramsey, Jon J
AU - Villaverde, Cecilia
AU - Asami, Danny K.
AU - Wei, Alfreda
AU - Fascetti, Andrea J
PY - 2008/6
Y1 - 2008/6
N2 - Cats require more dietary protein than noncarnivorous species. Earlier work showed that cats lack the ability to regulate hepatic urea cycle enzymes in response to dietary protein concentration. We thus hypothesized that cats are unable to fully adapt protein oxidation to protein intake, particularly at low-protein concentrations. We used indirect respiration calorimetry to assess cats' ability to adapt substrate oxidation to diets containing different concentrations of protein, including 1 below their protein requirement. Nine cats (5 males and 4 females; 2.7 ± 0.5 y; 4.49 ± 0.19 kg) consumed each of 4 semipurified diets containing 7.5% [low protein (LP3)], 14.2% [adequate protein (AP)], 27.1% [moderate protein (MP)], and 49.6% [high protein (HP)] of metabolizable energy from protein in a modified crossover design, beginning with the MP diet and then consuming the remaining diets in random order. After adaptation to each diet, cats completed a 5-d nitrogen balance trial and at least 2 12-h indirect calorimetry measurements. There was a significant effect of diet on protein oxidation (P < 0.0001), which measured 10.4 ± 0.5, 14.1 ± 1.0, 25.0 ± 1.7, and 53.2 ± 1.7% of total energy expenditure for the LP, AP, M,P and HP diets, respectively. The ratio of protein oxidation:protein intake was higher with the LP diet (1.39 ± 0.07) than the other 3 diets (AP, 1.00 ± 0.07; MP, 0.93 ± 0.06; HP, 1.07 ± 0.03; P < 0.0001), indicating a net loss of protein with the LP diet. Thus, cats are able to adapt protein oxidation to a wide range of dietary protein concentrations, provided their minimum protein requirement is met.
AB - Cats require more dietary protein than noncarnivorous species. Earlier work showed that cats lack the ability to regulate hepatic urea cycle enzymes in response to dietary protein concentration. We thus hypothesized that cats are unable to fully adapt protein oxidation to protein intake, particularly at low-protein concentrations. We used indirect respiration calorimetry to assess cats' ability to adapt substrate oxidation to diets containing different concentrations of protein, including 1 below their protein requirement. Nine cats (5 males and 4 females; 2.7 ± 0.5 y; 4.49 ± 0.19 kg) consumed each of 4 semipurified diets containing 7.5% [low protein (LP3)], 14.2% [adequate protein (AP)], 27.1% [moderate protein (MP)], and 49.6% [high protein (HP)] of metabolizable energy from protein in a modified crossover design, beginning with the MP diet and then consuming the remaining diets in random order. After adaptation to each diet, cats completed a 5-d nitrogen balance trial and at least 2 12-h indirect calorimetry measurements. There was a significant effect of diet on protein oxidation (P < 0.0001), which measured 10.4 ± 0.5, 14.1 ± 1.0, 25.0 ± 1.7, and 53.2 ± 1.7% of total energy expenditure for the LP, AP, M,P and HP diets, respectively. The ratio of protein oxidation:protein intake was higher with the LP diet (1.39 ± 0.07) than the other 3 diets (AP, 1.00 ± 0.07; MP, 0.93 ± 0.06; HP, 1.07 ± 0.03; P < 0.0001), indicating a net loss of protein with the LP diet. Thus, cats are able to adapt protein oxidation to a wide range of dietary protein concentrations, provided their minimum protein requirement is met.
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M3 - Article
VL - 138
SP - 1053
EP - 1060
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 6
ER -