Cation-chloride cotransporters in neuronal development, plasticity and disease.

Kai Kaila, Theodore J. Price, John A Payne, Martin Puskarjov, Juha Voipio

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K(+)-Cl(-) cotransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity. Studying the functions of these transporters may lead to major paradigm shifts in our understanding of the mechanisms underlying brain development and plasticity in health and disease.

Original languageEnglish (US)
Pages (from-to)637-654
Number of pages18
JournalNature reviews. Neuroscience
Volume15
Issue number10
DOIs
StatePublished - 2014

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Neuronal Plasticity
Cations
Chlorides
Ions
Ion Channels
Neurons
Health
Brain
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cation-chloride cotransporters in neuronal development, plasticity and disease. / Kaila, Kai; Price, Theodore J.; Payne, John A; Puskarjov, Martin; Voipio, Juha.

In: Nature reviews. Neuroscience, Vol. 15, No. 10, 2014, p. 637-654.

Research output: Contribution to journalArticle

Kaila, Kai ; Price, Theodore J. ; Payne, John A ; Puskarjov, Martin ; Voipio, Juha. / Cation-chloride cotransporters in neuronal development, plasticity and disease. In: Nature reviews. Neuroscience. 2014 ; Vol. 15, No. 10. pp. 637-654.
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