Cation-chloride co-transporters in neuronal communication, development and trauma

John A Payne, Claudio Rivera, Juha Voipio, Kai Kaila

Research output: Contribution to journalArticle

585 Citations (Scopus)

Abstract

Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate current and voltage responses by dissipating these gradients. Although both voltage- and ligand-gated channels are being extensively studied, the central role of ion pumps and carriers is largely ignored in current neuroscience. Such an information gap is particularly evident with regard to neuronal Cl- regulation, despite its immense importance in the generation of inhibitory synaptic responses by GABA- and glycine-gated anion channels. The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.

Original languageEnglish (US)
Pages (from-to)199-206
Number of pages8
JournalTrends in Neurosciences
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2003

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Ion Pumps
Symporters
Glycine
gamma-Aminobutyric Acid
Cations
Chlorides
Ligand-Gated Ion Channels
Neuronal Plasticity
Wounds and Injuries
Neurosciences
Ion Channels
Cell Communication
Anions
Ions
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cation-chloride co-transporters in neuronal communication, development and trauma. / Payne, John A; Rivera, Claudio; Voipio, Juha; Kaila, Kai.

In: Trends in Neurosciences, Vol. 26, No. 4, 01.04.2003, p. 199-206.

Research output: Contribution to journalArticle

Payne, John A ; Rivera, Claudio ; Voipio, Juha ; Kaila, Kai. / Cation-chloride co-transporters in neuronal communication, development and trauma. In: Trends in Neurosciences. 2003 ; Vol. 26, No. 4. pp. 199-206.
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