Abstract
Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate current and voltage responses by dissipating these gradients. Although both voltage- and ligand-gated channels are being extensively studied, the central role of ion pumps and carriers is largely ignored in current neuroscience. Such an information gap is particularly evident with regard to neuronal Cl- regulation, despite its immense importance in the generation of inhibitory synaptic responses by GABA- and glycine-gated anion channels. The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-206 |
| Number of pages | 8 |
| Journal | Trends in Neurosciences |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2003 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Cation-chloride co-transporters in neuronal communication, development and trauma. / Payne, John A; Rivera, Claudio; Voipio, Juha; Kaila, Kai.
In: Trends in Neurosciences, Vol. 26, No. 4, 01.04.2003, p. 199-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cation-chloride co-transporters in neuronal communication, development and trauma
AU - Payne, John A
AU - Rivera, Claudio
AU - Voipio, Juha
AU - Kaila, Kai
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate current and voltage responses by dissipating these gradients. Although both voltage- and ligand-gated channels are being extensively studied, the central role of ion pumps and carriers is largely ignored in current neuroscience. Such an information gap is particularly evident with regard to neuronal Cl- regulation, despite its immense importance in the generation of inhibitory synaptic responses by GABA- and glycine-gated anion channels. The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.
AB - Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate current and voltage responses by dissipating these gradients. Although both voltage- and ligand-gated channels are being extensively studied, the central role of ion pumps and carriers is largely ignored in current neuroscience. Such an information gap is particularly evident with regard to neuronal Cl- regulation, despite its immense importance in the generation of inhibitory synaptic responses by GABA- and glycine-gated anion channels. The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.
UR - http://www.scopus.com/inward/record.url?scp=0037384485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037384485&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(03)00068-7
DO - 10.1016/S0166-2236(03)00068-7
M3 - Article
C2 - 12689771
AN - SCOPUS:0037384485
VL - 26
SP - 199
EP - 206
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 4
ER -