Catheter electrode studies for ultra-short high-field pulses

Mya Thu, Matthew R. Behrend, P. Thomas Vernier, Yinghua Sun, Andras Kuthi, Laura Marcu, Martin A. Gundersen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultra-short (less than 30 ns) high-field (greater than 1.5 megavolt per meter (MV/m)) pulses have been shown to induce apoptosis in cultured cancer-derived cells. A potential clinical application of this phenomenon is to treat malignant and diseased tissues. This paper presents preliminary research on development and design of thin, flexible catheter electrodes to deliver nanosecond pulses for minimally invasive in vivo treatment applications. An evaluation of commercially available microwave cables and RF ablation catheters for compatibility with ultra-short pulse cancer therapy is presented. The results show that RF ablation catheters distort high frequency components of nanosecond pulses. Preliminary results of a prototype micro-coaxial catheter electrode for nanosecond pulse delivery applications are presented.

Original languageEnglish (US)
Title of host publicationConference Record of the International Power Modulator Symposium and High Voltage Workshop
Pages337-340
Number of pages4
StatePublished - 2004
Externally publishedYes
Event2004 IEEE International Power Modulator Conference: 26th International Power Modulator Symposium and 2004 High Voltage Workshop - San Francisco, CA, United States
Duration: May 23 2004May 26 2004

Other

Other2004 IEEE International Power Modulator Conference: 26th International Power Modulator Symposium and 2004 High Voltage Workshop
CountryUnited States
CitySan Francisco, CA
Period5/23/045/26/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Thu, M., Behrend, M. R., Vernier, P. T., Sun, Y., Kuthi, A., Marcu, L., & Gundersen, M. A. (2004). Catheter electrode studies for ultra-short high-field pulses. In Conference Record of the International Power Modulator Symposium and High Voltage Workshop (pp. 337-340)