Catecholamine uptake inhibitors elevate 6-hydroxydopamine in brain after administration of 6-hydroxydopa

Jacqueline Evans, Gerald Cohen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Desipramine and nomifensine, two norepinephrine uptake blockers, elevated by 63-248% the levels of 6-hydroxydopamine found in the frontal cortex at 1-4 h after administration of 6-OH-DOPA. Nomifensine also elevated 6-hydroxydopamine by 83% in the striatum at 4 h. These results nullify prior suggestions in the literature that 6-OH-DOPA is decarboxylated to 6-hydroxydopamine mainly outside of catecholamine nerve terminals and that 6-hydroxydopamine subsequently gains access to nerve terminals via the axonal membrane transport system for catecholamines.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalEuropean Journal of Pharmacology
Volume232
Issue number2-3
DOIs
StatePublished - Mar 2 1993
Externally publishedYes

Keywords

  • 6-Hydroxy-DOPA (2,4,5-trihydroxyphenylalanine)
  • 6-Hydroxydopamine (6-OHDA)
  • Desipramine
  • Neurotoxicity
  • Nomifensine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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