Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome

Joan Gunther, Yingfang Tian, Boryana Stamova, Lisa Lit, Blythe Corbett, Bradley Ander, Xinhua Zhan, Glen Jickling, Netty Bos-Veneman, Da Liu, Pieter Hoekstra, Frank R Sharp

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Tourette syndrome (TS) is a heritable disorder characterized by tics that are decreased in some patients by treatment with alpha adrenergic agonists and dopamine receptor blockers. Thus, this study examines the relationship between catecholamine gene expression in blood and tic severity. TS diagnosis was confirmed using Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria and tic severity measured using the Yale Global Tic Severity Scale (YGTSS) for 26 un-medicated subjects with TS. Whole blood was collected and Ribonucleic acid (RNA) processed on Affymetrix Human Exon 1.0 ST arrays. An Analysis of Covariance (ANCOVA) identified 3627 genes correlated with tic severity (p<0.05). Searches of Medical Subject Headings, Gene Ontology, Allen Mouse Brain Atlas, and PubMed determined genes associated with catecholamines and located in the basal ganglia. Using GeneCards, PubMed, and manual curation, seven genes associated with TS were further examined: DRD2, HRH3, MAOB, BDNF, SNAP25, SLC6A4, and SLC22A3. These genes are highly associated with TS and have also been implicated in other movement disorders, Attention Deficit Hyperactivity Disorder (ADHD), and Obsessive-Compulsive Disorder (OCD). Correlation of gene expression in peripheral blood with tic severity may allow inferences about catecholamine pathway dysfunction in TS subjects. Findings built on previous work suggest that at least some genes expressed peripherally are relevant for central nervous system (CNS) pathology in the brain of individuals with TS.

Original languageEnglish (US)
Pages (from-to)593-601
Number of pages9
JournalPsychiatry Research
Volume200
Issue number2-3
DOIs
StatePublished - Dec 30 2012

Fingerprint

Tics
Tourette Syndrome
Catecholamines
Gene Expression
Genes
PubMed
Diagnostic and Statistical Manual of Mental Disorders
Tic Disorders
Medical Subject Headings
Adrenergic alpha-Agonists
Receptors, Adrenergic, alpha
Gene Ontology
Dopamine Antagonists
Atlases
Obsessive-Compulsive Disorder
Brain-Derived Neurotrophic Factor
Dopamine Receptors
Movement Disorders
Brain
Attention Deficit Disorder with Hyperactivity

Keywords

  • ADHD
  • Basal ganglia
  • Catecholamine
  • OCD
  • Peripheral blood gene expression
  • Tourette syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome. / Gunther, Joan; Tian, Yingfang; Stamova, Boryana; Lit, Lisa; Corbett, Blythe; Ander, Bradley; Zhan, Xinhua; Jickling, Glen; Bos-Veneman, Netty; Liu, Da; Hoekstra, Pieter; Sharp, Frank R.

In: Psychiatry Research, Vol. 200, No. 2-3, 30.12.2012, p. 593-601.

Research output: Contribution to journalArticle

Gunther, Joan ; Tian, Yingfang ; Stamova, Boryana ; Lit, Lisa ; Corbett, Blythe ; Ander, Bradley ; Zhan, Xinhua ; Jickling, Glen ; Bos-Veneman, Netty ; Liu, Da ; Hoekstra, Pieter ; Sharp, Frank R. / Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome. In: Psychiatry Research. 2012 ; Vol. 200, No. 2-3. pp. 593-601.
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