Abstract
OBJECTIVE: A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT ValMet) is associated with prefrontal-dependent task performance in schizophrenia. We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder. METHODS: Unmedicated outpatients with schizotypal personality disorder (SPD; n=67) and non-schizotypal personality disorder (NSPD; n=154) by DSM-III-R, and normal control (NC; n=60) participants were genotyped at the COMT ValMet locus. Of these, 98 Caucasians (23 SPD, 52 NSPD and 23 NC) performed a brief neurocognitive battery: Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), California Verbal Learning Test (CVLT), Visuospatial Working Memory (DOT) and Visual Delayed Recall (Wechsler Memory Scale Visual Reproduction, WMS-VR). RESULTS: Allele distribution was not significantly different in the full sample (by χ) for the SPD group compared with either the NC or combined NC/NSPD groups. In analyses of variance of Caucasian individuals, the SPD group performance met or approached significantly worse performance than NC, NSPD or both groups, on the PASAT, CVLT and WMS-VR. In regression analyses of cognitive performance, the COMT genotype was significantly associated with performance on WCST and PASAT, independent of diagnosis, with the Val/Val genotype associated with the worse performance. CONCLUSIONS: (1) Allelic variation in COMT activity is unrelated to the diagnosis of SPD in this sample. (2) Individuals with SPD exhibit multiple deficits in prefrontal and temporal lobe-dependent tasks. (3) The COMT genotype is related to performance on prefrontal cortex-dependent tasks and may contribute to the deficit in prefrontal-dependent memory processes in SPD as it does in schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-124 |
| Number of pages | 8 |
| Journal | Psychiatric Genetics |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2006 |
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Keywords
- Catechol-O-methyltransferase
- Cognition
- Genetics
- Prefrontal cortex
- Schizotypal personality disorder
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Genetics
- Neuroscience(all)
Cite this
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. / Minzenberg, Michael J.; Xu, Ke; Mitropoulou, Vivian; Harvey, Philip D.; Finch, Thembi; Flory, Janine D.; New, Antonia S.; Goldman, David; Siever, Larry J.
In: Psychiatric Genetics, Vol. 16, No. 3, 06.2006, p. 117-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
AU - Minzenberg, Michael J.
AU - Xu, Ke
AU - Mitropoulou, Vivian
AU - Harvey, Philip D.
AU - Finch, Thembi
AU - Flory, Janine D.
AU - New, Antonia S.
AU - Goldman, David
AU - Siever, Larry J.
PY - 2006/6
Y1 - 2006/6
N2 - OBJECTIVE: A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT ValMet) is associated with prefrontal-dependent task performance in schizophrenia. We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder. METHODS: Unmedicated outpatients with schizotypal personality disorder (SPD; n=67) and non-schizotypal personality disorder (NSPD; n=154) by DSM-III-R, and normal control (NC; n=60) participants were genotyped at the COMT ValMet locus. Of these, 98 Caucasians (23 SPD, 52 NSPD and 23 NC) performed a brief neurocognitive battery: Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), California Verbal Learning Test (CVLT), Visuospatial Working Memory (DOT) and Visual Delayed Recall (Wechsler Memory Scale Visual Reproduction, WMS-VR). RESULTS: Allele distribution was not significantly different in the full sample (by χ) for the SPD group compared with either the NC or combined NC/NSPD groups. In analyses of variance of Caucasian individuals, the SPD group performance met or approached significantly worse performance than NC, NSPD or both groups, on the PASAT, CVLT and WMS-VR. In regression analyses of cognitive performance, the COMT genotype was significantly associated with performance on WCST and PASAT, independent of diagnosis, with the Val/Val genotype associated with the worse performance. CONCLUSIONS: (1) Allelic variation in COMT activity is unrelated to the diagnosis of SPD in this sample. (2) Individuals with SPD exhibit multiple deficits in prefrontal and temporal lobe-dependent tasks. (3) The COMT genotype is related to performance on prefrontal cortex-dependent tasks and may contribute to the deficit in prefrontal-dependent memory processes in SPD as it does in schizophrenia.
AB - OBJECTIVE: A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT ValMet) is associated with prefrontal-dependent task performance in schizophrenia. We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder. METHODS: Unmedicated outpatients with schizotypal personality disorder (SPD; n=67) and non-schizotypal personality disorder (NSPD; n=154) by DSM-III-R, and normal control (NC; n=60) participants were genotyped at the COMT ValMet locus. Of these, 98 Caucasians (23 SPD, 52 NSPD and 23 NC) performed a brief neurocognitive battery: Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), California Verbal Learning Test (CVLT), Visuospatial Working Memory (DOT) and Visual Delayed Recall (Wechsler Memory Scale Visual Reproduction, WMS-VR). RESULTS: Allele distribution was not significantly different in the full sample (by χ) for the SPD group compared with either the NC or combined NC/NSPD groups. In analyses of variance of Caucasian individuals, the SPD group performance met or approached significantly worse performance than NC, NSPD or both groups, on the PASAT, CVLT and WMS-VR. In regression analyses of cognitive performance, the COMT genotype was significantly associated with performance on WCST and PASAT, independent of diagnosis, with the Val/Val genotype associated with the worse performance. CONCLUSIONS: (1) Allelic variation in COMT activity is unrelated to the diagnosis of SPD in this sample. (2) Individuals with SPD exhibit multiple deficits in prefrontal and temporal lobe-dependent tasks. (3) The COMT genotype is related to performance on prefrontal cortex-dependent tasks and may contribute to the deficit in prefrontal-dependent memory processes in SPD as it does in schizophrenia.
KW - Catechol-O-methyltransferase
KW - Cognition
KW - Genetics
KW - Prefrontal cortex
KW - Schizotypal personality disorder
UR - http://www.scopus.com/inward/record.url?scp=33746781825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746781825&partnerID=8YFLogxK
U2 - 10.1097/01.ypg.0000199448.00163.e6
DO - 10.1097/01.ypg.0000199448.00163.e6
M3 - Article
C2 - 16691129
AN - SCOPUS:33746781825
VL - 16
SP - 117
EP - 124
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 3
ER -