Catalytic C-H amination for the preparation of substituted 1,2-diamines

David Olson; J. Du Bois

doi:10.1021/ja803344v

Catalytic C-H amination for the preparation of substituted 1,2-diamines

David Olson, J. Du Bois

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.

Original language	English (US)
Pages (from-to)	11248-11249
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	34
DOIs	https://doi.org/10.1021/ja803344v
State	Published - Aug 27 2008
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja803344v

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abstract = "Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.",

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N2 - Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.

AB - Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.

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Catalytic C-H amination for the preparation of substituted 1,2-diamines

Abstract

ASJC Scopus subject areas

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