Abstract
A new catalytic synthesis of densely substituted tetrahydroquinolines is described. This reaction forms up to two rings, three bonds, and three stereogenic centers with excellent stereo- and regiocontrol in a single step. Although control experiments demonstrate that the active catalyst is protic acid, Sc(OTf)3 serves as an effective and practical pre-catalyst. The scope of this reaction is demonstrated with 21 monocyclizations and 14 bicyclization reactions.
Original language | English (US) |
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Pages (from-to) | 292-296 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - 2013 |
ASJC Scopus subject areas
- Chemistry(all)