Abstract
AMPA-type glutamate receptors (AMPARs) are clustered into functional nanodomains at postsynaptic sites through anchorage by the scaffolding protein, postsynaptic density protein-95 (PSD-95). The synaptic abundance of AMPARs is dynamically controlled in various forms of synaptic plasticity. Removal of AMPARs from the synapse in long-term depression (LTD) requires mobilization of PSD-95 away from the synapse. The molecular mechanisms underlying PSD-95 dispersal from the synapse during LTD are not completely understood. Here we show that, following Ca2+ influx, binding of Ca2+/calmodulin (CaM) to PSD-95 triggers loss of synaptic PSD-95 as well as surface AMPARs during chemically induced LTD in cultured rat neurons. Our data suggest that a reduction in PSD-95 palmitoylation mediates the effect of Ca2+/CaM on PSD-95 synaptic levels during LTD. These findings reveal a novel molecular mechanism for synaptic AMPAR regulation in LTD.
Original language | English (US) |
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Article number | 6 |
Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Frontiers in Synaptic Neuroscience |
Volume | 11 |
DOIs | |
State | Published - 2019 |
Keywords
- AMPAR
- LTD
- Palmitoylation
- PSD-95
- Synapse
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology