Ca2+ waves in the heart

Leighton T Izu, Yuanfang Xie, Daisuke Sato, Tamás Bányász, Ye Chen-Izu

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Ca2+ waves were probably first observed in the early 1940s. Since then Ca2+ waves have captured the attention of an eclectic mixture of mathematicians, neuroscientists, muscle physiologists, developmental biologists, and clinical cardiologists. This review discusses the current state of mathematical models of Ca2+ waves, the normal physiological functions Ca2+ waves might serve in cardiac cells, as well as how the spatial arrangement of Ca2+ release channels shape Ca2+ waves, and we introduce the idea of Ca2+ phase waves that might provide a useful framework for understanding triggered arrhythmias. This article is part of a Special Issue entitled "Calcium Signaling in Heart".

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Issue number1
StatePublished - May 2013


  • Arrhythmias
  • Ca sparks
  • Ca waves
  • Mathematical models

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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