Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle

Francisco Altamirano, Jóse M. Eltit, Gaëlle Robin, Nancy Linares, Xudong Ding, Isaac N Pessah, Paul D. Allen, José R. López

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca 2+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca 2+ transients induced by high [K+]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca2+ dynamics in MH muscle.

Original languageEnglish (US)
Pages (from-to)19180-19190
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
StatePublished - Jul 4 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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    Altamirano, F., Eltit, J. M., Robin, G., Linares, N., Ding, X., Pessah, I. N., Allen, P. D., & López, J. R. (2014). Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. Journal of Biological Chemistry, 289(27), 19180-19190. https://doi.org/10.1074/jbc.M114.550764