Ca2+ flux through promiscuous cardiac Na+ channels: Slip-mode conductance

Luis Fernando Santana, A. M. Gómez, W. J. Lederer

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


The tetrodotoxin-sensitive sodium ion (Na+) channel is opened by cellular depolarization and favors the passage of Na+ over other ions. Activation of the β-adrenergic receptor or protein kinase A in rat heart cells transformed this Na+ channel into one that is promiscuous with respect to ion selectivity, permitting calcium ions (Ca2+) to permeate as readily as Na+. Similarly, nanomolar concentrations of cardiotonic steroids such as ouabain and digoxin switched the ion selectivity of the NA+ channel to this state of promiscuous permeability called slip-mode conductance. Slip-mode conductance o the Na+ channel can contribute significantly to local and global cardiac Ca2+ signaling and may be a general signaling mechanism in excitable cells.

Original languageEnglish (US)
Pages (from-to)1027-1033
Number of pages7
Issue number5353
StatePublished - Feb 13 1998
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • General


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