Case report

Muscle adaptation by serial sarcomere addition 1 year after femoral lengthening

Jennette Boakes, Jared Foran, Samuel R. Ward, Richard L. Lieber

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A common complication of reconstructive surgery is muscle contracture and consequent loss of joint motion. This particularly occurs in surgical lengthening procedures where the muscle adaptive capacity seems to limit the extent of possible lengthening. We used intraoperative laser diffraction to determine the skeletal muscle adaptation that occurred in a 16-year-old girl who had 4-cm femoral lengthening for a leg-length discrepancy secondary to posttraumatic growth arrest. Fascicle length changed dramatically during distraction from a starting value of approximately 9 cm to a new length of 19 cm. In vivo vastus lateralis sarcomere length measured intraoperatively at the initial surgery was 3.64 μm, whereas sarcomere length measured 8 months later was 3.11 μm. The fact that fascicle length increased dramatically and in vivo sarcomere length decreased slightly reveals an increase in serial sarcomeres from 25,000 to 58,650. This direct measurement of fascicle length and sarcomere length confirms sarcomerogenesis in human skeletal muscle secondary to chronic length change, and shows the capacity of human muscle to adapt to length changes.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalClinical Orthopaedics and Related Research
Issue number456
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Sarcomeres
Thigh
Muscles
Reconstructive Surgical Procedures
Skeletal Muscle
Quadriceps Muscle
Contracture
Leg
Lasers
Joints
Growth

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Case report : Muscle adaptation by serial sarcomere addition 1 year after femoral lengthening. / Boakes, Jennette; Foran, Jared; Ward, Samuel R.; Lieber, Richard L.

In: Clinical Orthopaedics and Related Research, No. 456, 2007, p. 250-253.

Research output: Contribution to journalArticle

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