Case-Control Studies of Estrogens and Endometrial Cancer

William D. Dupont, Peter Franks, W. P. Soutter, Clifford R. Kay, Frank Cole, Richard K. Donelson, Alvan R. Feinstein, Ralph I. Horwitz, George B. Hutchison

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: In their editorial1 criticizing the Horwitz and Feinstein paper on endometrial cancer,2 Hutchison and Rothman claim that a sample of patients with endometrial cancer selected from a gynecologic-cancer treatment center will be unbiased for estrogen usage. Their argument is based on the premise that cancer is a progressive disease that inevitably leads to diagnosis. Thus, although estrogen-induced bleeding may cause earlier treatment, the patient with cancer who took estrogen will be no more likely to be selected as a case than the one who did not. The premise of inevitable diagnosis requires, however, that the rate of.

Original languageEnglish (US)
Pages (from-to)495-497
Number of pages3
JournalNew England Journal of Medicine
Issue number9
StatePublished - Mar 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Case-Control Studies of Estrogens and Endometrial Cancer'. Together they form a unique fingerprint.

Cite this