Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma

Vincent L. Biron, Eric J. Lentsch, Daniel R. Gerry, Arnaud Bewley

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Acinic cell carcinoma (AciCC) is an uncommon malignant-epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English-language literature. Methods: We performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009. Results: Patient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low-grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment-matched cohort of parotid AciCC, we found a lower 10-year overall survival (52.3%) with no significant difference in disease-specific survival (88.9%). Our meta-analysis of survival from cases in the literature estimated 10-year recurrence-free survival at 92.9%. Conclusion: To our knowledge, this is the largest cohort of patients with AciCC reported in the English-language literature. Our results suggest that patients with sinonasal AciCC have excellent disease-specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalInternational Forum of Allergy and Rhinology
Volume4
Issue number6
DOIs
StatePublished - 2014

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Acinar Cell Carcinoma
Survival Analysis
Survival
Language
Salivary Gland Neoplasms
Salivary Glands
Meta-Analysis
Neoplasms
Epidemiology
Demography
Databases
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

Cite this

Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma. / Biron, Vincent L.; Lentsch, Eric J.; Gerry, Daniel R.; Bewley, Arnaud.

In: International Forum of Allergy and Rhinology, Vol. 4, No. 6, 2014, p. 507-511.

Research output: Contribution to journalArticle

Biron, Vincent L. ; Lentsch, Eric J. ; Gerry, Daniel R. ; Bewley, Arnaud. / Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma. In: International Forum of Allergy and Rhinology. 2014 ; Vol. 4, No. 6. pp. 507-511.
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