Abstract
Background: Acinic cell carcinoma (AciCC) is an uncommon malignant-epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English-language literature. Methods: We performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009. Results: Patient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low-grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment-matched cohort of parotid AciCC, we found a lower 10-year overall survival (52.3%) with no significant difference in disease-specific survival (88.9%). Our meta-analysis of survival from cases in the literature estimated 10-year recurrence-free survival at 92.9%. Conclusion: To our knowledge, this is the largest cohort of patients with AciCC reported in the English-language literature. Our results suggest that patients with sinonasal AciCC have excellent disease-specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 507-511 |
| Number of pages | 5 |
| Journal | International Forum of Allergy and Rhinology |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2014 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Otorhinolaryngology
Cite this
Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma. / Biron, Vincent L.; Lentsch, Eric J.; Gerry, Daniel R.; Bewley, Arnaud.
In: International Forum of Allergy and Rhinology, Vol. 4, No. 6, 2014, p. 507-511.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Case-control analysis of survival outcomes in sinonasal acinic cell carcinoma
AU - Biron, Vincent L.
AU - Lentsch, Eric J.
AU - Gerry, Daniel R.
AU - Bewley, Arnaud
PY - 2014
Y1 - 2014
N2 - Background: Acinic cell carcinoma (AciCC) is an uncommon malignant-epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English-language literature. Methods: We performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009. Results: Patient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low-grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment-matched cohort of parotid AciCC, we found a lower 10-year overall survival (52.3%) with no significant difference in disease-specific survival (88.9%). Our meta-analysis of survival from cases in the literature estimated 10-year recurrence-free survival at 92.9%. Conclusion: To our knowledge, this is the largest cohort of patients with AciCC reported in the English-language literature. Our results suggest that patients with sinonasal AciCC have excellent disease-specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.
AB - Background: Acinic cell carcinoma (AciCC) is an uncommon malignant-epithelial salivary gland cancer. In very rare cases, this tumor may arise from sinonasal subsites, with only 19 cases described in the English-language literature. Methods: We performed a retrospective analysis of 18 cases of AciCC, obtained from searching the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2009. Results: Patient demographics, including age, gender, and race, were similar to AciCC cases found in more common locations. However, all patients had low-grade tumors without regional or distant metastases. Comparing these patients to a stage, grade, and treatment-matched cohort of parotid AciCC, we found a lower 10-year overall survival (52.3%) with no significant difference in disease-specific survival (88.9%). Our meta-analysis of survival from cases in the literature estimated 10-year recurrence-free survival at 92.9%. Conclusion: To our knowledge, this is the largest cohort of patients with AciCC reported in the English-language literature. Our results suggest that patients with sinonasal AciCC have excellent disease-specific survival, comparable to matched patients with AciCC in more common salivary gland subsites.
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UR - http://www.scopus.com/inward/citedby.url?scp=84901856234&partnerID=8YFLogxK
U2 - 10.1002/alr.21301
DO - 10.1002/alr.21301
M3 - Article
C2 - 24599557
AN - SCOPUS:84901856234
VL - 4
SP - 507
EP - 511
JO - International Forum of Allergy and Rhinology
JF - International Forum of Allergy and Rhinology
SN - 2042-6976
IS - 6
ER -