Abstract
The potential association between fetal death and residential proximity to agricultural pesticide applications was examined in 10 California counties for 1984. A case-cohort analysis utilized 319 cases of selected causes of fetal death other than congenital anomalies and 611 noncases. A statewide database of all applications of restricted pesticides was linked to maternal address; residential proximity within 1 mile (1.6 km) provided a surrogate for daily exposure. Pesticides were grouped by chemical class and mechanism of acetylcholinesterase inhibition. Multivariate proportional hazards models using time-dependent exposure variables were fit for each pesticide grouping. Overall, pesticides showed no strong association with fetal death. Slightly elevated risks were observed for women who resided near applications of halogenated hydrocarbons, carbamates, estrogenic pesticides, and carbamate acetylcholinesterase inhibitors during the second trimester, with hazard ratios of 1.3 (95% confidence interval (Cl): 1.0, 1.8), 1.3 (95% Cl: 1.0, 1.8), 1.4 (95% Cl: 0.8, 2.5), and 1.3 (95% Cl: 1.0, 1.8), respectively. In a month-by-month analysis, elevated risks were observed when exposure occurred during gestational months 3 and 4 for carbamates and carbamate inhibitors and during months 4 and 5 for halogenated hydrocarbons. Since previous studies have relied on personal recall of exposure, major strengths of this study were the objective source for environmental pesticide exposure assessment and the use of data on the timing of exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 702-710 |
| Number of pages | 9 |
| Journal | American Journal of Epidemiology |
| Volume | 154 |
| Issue number | 8 |
| DOIs | |
| State | Published - Oct 15 2001 |
| Externally published | Yes |
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Keywords
- Environmental exposure
- Fetal death
- Pesticides
- Pregnancy outcome
- Survival analysis
ASJC Scopus subject areas
- Epidemiology
Cite this
Case-cohort analysis of agricultural pesticide applications near maternal residence and selected causes of fetal death. / Bell, Erin M.; Hertz-Picciotto, Irva; Beaumont, James J.
In: American Journal of Epidemiology, Vol. 154, No. 8, 15.10.2001, p. 702-710.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Case-cohort analysis of agricultural pesticide applications near maternal residence and selected causes of fetal death
AU - Bell, Erin M.
AU - Hertz-Picciotto, Irva
AU - Beaumont, James J.
PY - 2001/10/15
Y1 - 2001/10/15
N2 - The potential association between fetal death and residential proximity to agricultural pesticide applications was examined in 10 California counties for 1984. A case-cohort analysis utilized 319 cases of selected causes of fetal death other than congenital anomalies and 611 noncases. A statewide database of all applications of restricted pesticides was linked to maternal address; residential proximity within 1 mile (1.6 km) provided a surrogate for daily exposure. Pesticides were grouped by chemical class and mechanism of acetylcholinesterase inhibition. Multivariate proportional hazards models using time-dependent exposure variables were fit for each pesticide grouping. Overall, pesticides showed no strong association with fetal death. Slightly elevated risks were observed for women who resided near applications of halogenated hydrocarbons, carbamates, estrogenic pesticides, and carbamate acetylcholinesterase inhibitors during the second trimester, with hazard ratios of 1.3 (95% confidence interval (Cl): 1.0, 1.8), 1.3 (95% Cl: 1.0, 1.8), 1.4 (95% Cl: 0.8, 2.5), and 1.3 (95% Cl: 1.0, 1.8), respectively. In a month-by-month analysis, elevated risks were observed when exposure occurred during gestational months 3 and 4 for carbamates and carbamate inhibitors and during months 4 and 5 for halogenated hydrocarbons. Since previous studies have relied on personal recall of exposure, major strengths of this study were the objective source for environmental pesticide exposure assessment and the use of data on the timing of exposure.
AB - The potential association between fetal death and residential proximity to agricultural pesticide applications was examined in 10 California counties for 1984. A case-cohort analysis utilized 319 cases of selected causes of fetal death other than congenital anomalies and 611 noncases. A statewide database of all applications of restricted pesticides was linked to maternal address; residential proximity within 1 mile (1.6 km) provided a surrogate for daily exposure. Pesticides were grouped by chemical class and mechanism of acetylcholinesterase inhibition. Multivariate proportional hazards models using time-dependent exposure variables were fit for each pesticide grouping. Overall, pesticides showed no strong association with fetal death. Slightly elevated risks were observed for women who resided near applications of halogenated hydrocarbons, carbamates, estrogenic pesticides, and carbamate acetylcholinesterase inhibitors during the second trimester, with hazard ratios of 1.3 (95% confidence interval (Cl): 1.0, 1.8), 1.3 (95% Cl: 1.0, 1.8), 1.4 (95% Cl: 0.8, 2.5), and 1.3 (95% Cl: 1.0, 1.8), respectively. In a month-by-month analysis, elevated risks were observed when exposure occurred during gestational months 3 and 4 for carbamates and carbamate inhibitors and during months 4 and 5 for halogenated hydrocarbons. Since previous studies have relied on personal recall of exposure, major strengths of this study were the objective source for environmental pesticide exposure assessment and the use of data on the timing of exposure.
KW - Environmental exposure
KW - Fetal death
KW - Pesticides
KW - Pregnancy outcome
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=0035887896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035887896&partnerID=8YFLogxK
U2 - 10.1093/aje/154.8.702
DO - 10.1093/aje/154.8.702
M3 - Article
C2 - 11590082
AN - SCOPUS:0035887896
VL - 154
SP - 702
EP - 710
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 8
ER -