Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis

Chitrangada Acharya, Jasper H N Yik, Ashleen Kishore, Victoria Van Dinh, Paul E. Di Cesare, Dominik R Haudenschild

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular proteins. While these proteins belong to the same family, they are encoded by different genes, regulate different cellular functions and are localized to specific regions of the body. TSP-5 or Cartilage Oligomeric Matrix Protein (COMP) is the only TSP that has been associated with skeletal disorders in humans, including pseudo. achondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). The pentameric structure of COMP, the evidence that it interacts with multiple cellular proteins, and the recent reports of COMP acting as a 'lattice' to present growth factors to cells, inspired this review of COMP and its interacting partners. In our review, we have compiled the interactions of COMP with other proteins in the cartilage extracellular matrix and summarized their importance in maintaining the structural integrity of cartilage as well as in regulating cellular functions.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalMatrix Biology
Volume37
DOIs
StatePublished - Jul 1 2014

Fingerprint

Cartilage Oligomeric Matrix Protein
Chondrogenesis
Protein Binding
Cartilage
Extracellular Matrix
Thrombospondins
Achondroplasia
Osteochondrodysplasias
Body Regions
Proteins
Calcium-Binding Proteins
Intercellular Signaling Peptides and Proteins
Genes

Keywords

  • Cartilage oligomeric matrix protein
  • Complement system
  • Extracellular matrix
  • Growth factors
  • Proteases
  • Receptors

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix : Interaction, regulation and role in chondrogenesis. / Acharya, Chitrangada; Yik, Jasper H N; Kishore, Ashleen; Van Dinh, Victoria; Di Cesare, Paul E.; Haudenschild, Dominik R.

In: Matrix Biology, Vol. 37, 01.07.2014, p. 102-111.

Research output: Contribution to journalArticle

Acharya, Chitrangada ; Yik, Jasper H N ; Kishore, Ashleen ; Van Dinh, Victoria ; Di Cesare, Paul E. ; Haudenschild, Dominik R. / Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix : Interaction, regulation and role in chondrogenesis. In: Matrix Biology. 2014 ; Vol. 37. pp. 102-111.
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