Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis

Chitrangada Acharya, Jasper H N Yik, Ashleen Kishore, Victoria Van Dinh, Paul E. Di Cesare, Dominik R Haudenschild

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular proteins. While these proteins belong to the same family, they are encoded by different genes, regulate different cellular functions and are localized to specific regions of the body. TSP-5 or Cartilage Oligomeric Matrix Protein (COMP) is the only TSP that has been associated with skeletal disorders in humans, including pseudo. achondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). The pentameric structure of COMP, the evidence that it interacts with multiple cellular proteins, and the recent reports of COMP acting as a 'lattice' to present growth factors to cells, inspired this review of COMP and its interacting partners. In our review, we have compiled the interactions of COMP with other proteins in the cartilage extracellular matrix and summarized their importance in maintaining the structural integrity of cartilage as well as in regulating cellular functions.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalMatrix Biology
Volume37
DOIs
StatePublished - Jul 1 2014

Keywords

  • Cartilage oligomeric matrix protein
  • Complement system
  • Extracellular matrix
  • Growth factors
  • Proteases
  • Receptors

ASJC Scopus subject areas

  • Molecular Biology

Fingerprint Dive into the research topics of 'Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis'. Together they form a unique fingerprint.

  • Cite this