Cartilage morphology and T and T2 quantification in ACL-reconstructed knees: A 2-year follow-up

F. Su, J. F. Hilton, Lorenzo Nardo, S. Wu, F. Liang, T. M. Link, C. B. Ma, X. Li

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Objective: To describe cartilage matrix and morphology changes, assessed using quantitative magnetic resonance imaging (MRI), after acute anterior cruciate ligament (ACL) injury relative to controls and longitudinally during 2 years following reconstruction. Method: Fifteen patients with acute ACL injuries and 16 healthy volunteers with a similar demographic profile but no history of osteoarthritis or knee injury were studied. The injured knee of each participant was imaged with a 3.0T MR scanner at baseline (prior to ACL reconstruction); patients' knees were re-imaged 1and 2 years after ACL reconstruction. Cartilage T and T2 values in full thickness, superficial layers, and deep layers, and cartilage thickness of the full layer were quantified within subcompartments of the knee joint. Results: In the posterolateral tibial cartilage, T values were significantly higher in ACL-injured knees than control knees at baseline and were not fully recovered 2 after ACL reconstruction. T values of medial tibiofemoral cartilage in ACL-injured knees increased over the 2-year study and were significantly elevated compared to that of the control knees. T2 values in cartilage of the central aspect of the medial femoral condyle at the 2-year follow-up were significantly elevated compared with control knees. Cartilage in the posterior regions of the lateral tibia was significantly thinner, while cartilage in the central aspect of the medial femur was significantly thicker than that of controls. Patients with lesions in the posterior horn of the medial meniscus exhibited significantly higher T values in weight-bearing regions of the tibiofemoral cartilage than that of control subjects over the 2-year period, whereas patients without medial meniscal tears did not. Conclusion: Quantitative MRI provides powerful invivo tools to quantitatively evaluate early changes of cartilage matrix and morphology after acute ACL injury and reconstruction, which may possibly relate to the development of post-traumatic osteoarthritis in such joints.

Original languageEnglish (US)
Pages (from-to)1058-1067
Number of pages10
JournalOsteoarthritis and Cartilage
Issue number8
StatePublished - Aug 1 2013
Externally publishedYes


  • Anterior cruciate ligament
  • Cartilage
  • Magnetic resonance imaging
  • Post-traumatic osteoarthritis
  • T
  • T

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine
  • Biomedical Engineering


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