Abstract
Purpose: To describe a scoring system for quantification of cartilage lesions (Cartilage Lesion Score [CaLS]), to determine its reproducibility, to examine the association of CaLSdetected longitudinal change with known risk factors for osteoarthritis (OA) progression by comparing a group of subjects with OA risk factors with a group of subjects without OA risk factors, and to compare the CaLS system with the established semiquantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston- Leeds Osteoarthritis Knee Score (BLOKS) systems in terms of detection of cartilage defect progression. Materials and Methods: All subjects provided written informed consent, and the local institutional review board approved this HIPAAcompliant study. Fifty-two subjects with and 25 subjects without risk factors for knee OA were randomly selected from the Osteoarthritis Initiative. Inclusion criteria were age of 45-60 years, body mass index of 19-27 kg/m2, and no knee pain or OA on radiographs at baseline. Baseline and 24-month follow-up right knee 3-T magnetic resonance images were analyzed with WORMS, BLOKS, and CaLS systems. Progression of cartilage lesions with each scoring system was compared by using multilevel mixedeffects linear-regression models. κ values were calculated to determine reliability. Results: Intraclass coefficient values for inter- and intraobserver reliability of the CaLS system were 0.86 and 0.91, respectively. Interobserver k value range for individual features was 0.81-0.94. The CaLS system enabled significantly higher detection of cartilage lesion progression than did WORMS or BLOKS systems (P < .001); 51.8% (56 of 108), 17.6% (19 of 108), and 13.0% (14 of 108) of the lesions progressed when analyzed with the CaLS, WORMS, and BLOKS systems, respectively. With the CaLS system, subjects with OA risk factors had significantly higher odds of progression than did subjects without risk factors (odds ratio, 2.78; P = .005). Conclusion: The CaLS system is a reproducible scoring system for cartilage lesions that yields an improved detection rate for monitoring progression when compared with detection rates of semiquantitative WORMS and BLOKS systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 479-487 |
| Number of pages | 9 |
| Journal | Radiology |
| Volume | 271 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Cartilage lesion score : Comparison of a quantitative assessment score with established semiquantitative MR scoring systems. / Alizai, Hamza; Virayavanich, Warapat; Joseph, Gabby B.; Nardo, Lorenzo; Liu, Felix; Liebl, Hans; Nevitt, Michael C.; Lynch, John A.; McCulloch, Charles E.; Link, Thomas M.
In: Radiology, Vol. 271, No. 2, 01.01.2014, p. 479-487.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cartilage lesion score
T2 - Comparison of a quantitative assessment score with established semiquantitative MR scoring systems
AU - Alizai, Hamza
AU - Virayavanich, Warapat
AU - Joseph, Gabby B.
AU - Nardo, Lorenzo
AU - Liu, Felix
AU - Liebl, Hans
AU - Nevitt, Michael C.
AU - Lynch, John A.
AU - McCulloch, Charles E.
AU - Link, Thomas M.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Purpose: To describe a scoring system for quantification of cartilage lesions (Cartilage Lesion Score [CaLS]), to determine its reproducibility, to examine the association of CaLSdetected longitudinal change with known risk factors for osteoarthritis (OA) progression by comparing a group of subjects with OA risk factors with a group of subjects without OA risk factors, and to compare the CaLS system with the established semiquantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston- Leeds Osteoarthritis Knee Score (BLOKS) systems in terms of detection of cartilage defect progression. Materials and Methods: All subjects provided written informed consent, and the local institutional review board approved this HIPAAcompliant study. Fifty-two subjects with and 25 subjects without risk factors for knee OA were randomly selected from the Osteoarthritis Initiative. Inclusion criteria were age of 45-60 years, body mass index of 19-27 kg/m2, and no knee pain or OA on radiographs at baseline. Baseline and 24-month follow-up right knee 3-T magnetic resonance images were analyzed with WORMS, BLOKS, and CaLS systems. Progression of cartilage lesions with each scoring system was compared by using multilevel mixedeffects linear-regression models. κ values were calculated to determine reliability. Results: Intraclass coefficient values for inter- and intraobserver reliability of the CaLS system were 0.86 and 0.91, respectively. Interobserver k value range for individual features was 0.81-0.94. The CaLS system enabled significantly higher detection of cartilage lesion progression than did WORMS or BLOKS systems (P < .001); 51.8% (56 of 108), 17.6% (19 of 108), and 13.0% (14 of 108) of the lesions progressed when analyzed with the CaLS, WORMS, and BLOKS systems, respectively. With the CaLS system, subjects with OA risk factors had significantly higher odds of progression than did subjects without risk factors (odds ratio, 2.78; P = .005). Conclusion: The CaLS system is a reproducible scoring system for cartilage lesions that yields an improved detection rate for monitoring progression when compared with detection rates of semiquantitative WORMS and BLOKS systems.
AB - Purpose: To describe a scoring system for quantification of cartilage lesions (Cartilage Lesion Score [CaLS]), to determine its reproducibility, to examine the association of CaLSdetected longitudinal change with known risk factors for osteoarthritis (OA) progression by comparing a group of subjects with OA risk factors with a group of subjects without OA risk factors, and to compare the CaLS system with the established semiquantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston- Leeds Osteoarthritis Knee Score (BLOKS) systems in terms of detection of cartilage defect progression. Materials and Methods: All subjects provided written informed consent, and the local institutional review board approved this HIPAAcompliant study. Fifty-two subjects with and 25 subjects without risk factors for knee OA were randomly selected from the Osteoarthritis Initiative. Inclusion criteria were age of 45-60 years, body mass index of 19-27 kg/m2, and no knee pain or OA on radiographs at baseline. Baseline and 24-month follow-up right knee 3-T magnetic resonance images were analyzed with WORMS, BLOKS, and CaLS systems. Progression of cartilage lesions with each scoring system was compared by using multilevel mixedeffects linear-regression models. κ values were calculated to determine reliability. Results: Intraclass coefficient values for inter- and intraobserver reliability of the CaLS system were 0.86 and 0.91, respectively. Interobserver k value range for individual features was 0.81-0.94. The CaLS system enabled significantly higher detection of cartilage lesion progression than did WORMS or BLOKS systems (P < .001); 51.8% (56 of 108), 17.6% (19 of 108), and 13.0% (14 of 108) of the lesions progressed when analyzed with the CaLS, WORMS, and BLOKS systems, respectively. With the CaLS system, subjects with OA risk factors had significantly higher odds of progression than did subjects without risk factors (odds ratio, 2.78; P = .005). Conclusion: The CaLS system is a reproducible scoring system for cartilage lesions that yields an improved detection rate for monitoring progression when compared with detection rates of semiquantitative WORMS and BLOKS systems.
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U2 - 10.1148/radiol.13122056
DO - 10.1148/radiol.13122056
M3 - Article
VL - 271
SP - 479
EP - 487
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -