Cartilage-derived morphogenetic proteins and cartilage morphogenesis

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Cartilage morphogenesis is a prerequisite for skeletal development and maintenance. The morphogenesis of cartilage determines the shape of bones, and joints including articular cartilage, ligaments, and tendon. This article reviews the recent advances in cartilage-derived morphogenetic proteins (CDMPs) and related bone morphogenetic proteins (BMPs). Cartilage-derived morphogenetic proteins (CDMPs) are related to BMPs and are critical for cartilage and joint morphogenesis. Cartilage morphogenesis is a multistep cascade that includes factors for initiation, promotion, and maintenance of cartilage phenotype. The extracellular matrix of cartilage consists of a constellation of macromolecules as collagens, proteoglycans, and glycoproteins. Morphogens bind to extracellular matrix components and assemble a morphogenetic scaffold. Recent advances in CDMPs may aid in articular cartilage repair and regeneration.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalMicroscopy Research and Technique
Volume43
Issue number2
DOIs
StatePublished - Oct 15 1998

Keywords

  • Bone morphogenetic proteins
  • Cartilage-derived morphogenetic proteins
  • Insulin-like growth factors
  • Platelet- derived growth factor
  • Transforming growth factor β

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

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