Abstract
Background Although intensity-modulated radiotherapy (IMRT) is a standard of care for many head and neck cancers, its use for carotid-sparing (CS) therapy in early-stage laryngeal carcinoma is controversial. Methods 330 consecutive patients with early-stage laryngeal carcinoma were treated from 1/1989 to 5/2011, including 282 conventional radiotherapy (CRT) and 48 CS-IMRT patients. The median follow-up was 43 (CS-IMRT) and 66 (CRT) months. Results There was no difference in local failure rates comparing patients undergoing CS-IMRT with CRT, with 3-year local control rates of 88% vs. 89%, respectively (p = 0.938). Using a 1 cm circumferential margin, the average dose to the left and right carotid arteries was 48.3 and 47.9 Gy, respectively. 88% of locoregional recurrences involved the ipsilateral true vocal cord, including all local recurrences in the IMRT group. Conclusions These results warrant further prospective evaluation of CS-IMRT for early-stage glottic larynx cancer.
Original language | English (US) |
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Pages (from-to) | 716-723 |
Number of pages | 8 |
Journal | Oral Oncology |
Volume | 51 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2015 |
Externally published | Yes |
Keywords
- Carotid sparing
- Early stage laryngeal carcinoma
- Glottic cancer
- IMRT
ASJC Scopus subject areas
- Oral Surgery
- Oncology
- Cancer Research