Cardiovascular tolerance of intravenous lidocaine in broiler chickens (Gallus gallus domesticus) anesthetized with isoflurane

João Brandão, Anderson F. da Cunha, Bruno H Pypendop, Rhett Stout, Javier Nevarez, Thomas N. Tully

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To determine the cardiovascular effects of lidocaine infused intravenously (IV) in broiler chickens. Study design: Two phase study: Phase 1, randomized up-and-down study to determine effective dose 50 (ED<inf>50</inf>) for lidocaine; Phase 2, prospective randomized study to determine the cardiovascular effects of lidocaine. Animals: Seventeen Ross-708 broiler chickens (Gallus gallus domesticus) [11 chickens (Phase 1) and 6 chickens (Phase 2)], weighing 2.6-4.3 kg. Methods: After induction of anesthesia with isoflurane and placement of monitoring equipment including invasive blood pressure, chickens were administered lidocaine IV. During Phase 1, using an up-and-down design, each animal received a variable dose selected based on the response of the previous animal. During Phase 2, each animal was administered 6 mg kg<sup>-1</sup> of lidocaine IV over 2 minutes. Clinically irrelevant cardiovascular effects were defined as a relative decrease of heart rate (HR) and mean blood pressure (MAP) <30% subsequent to IV lidocaine administration. The ED<inf>50</inf> was defined as the dose rate that would cause clinically irrelevant cardiovascular depression in 50% of the population. Results: During Phase 1, using an up-and-down study design (n = 11), the ED<inf>50</inf> of lidocaine was determined to be 6.30 mg kg<sup>-1</sup> and 6.22 mg kg<sup>-1</sup> (95% confidence interval, 5.30-7.13 mg kg<sup>-1</sup>), when calculated by Dixon's up-and-down method, and logistic regression, respectively. During Phase 2, following infusion of lidocaine (6 mg kg<sup>-1</sup>), no clinically relevant effects on HR or MAP were detected in any animal. Conclusions and clinical relevance: Previous reports state that the dose of lidocaine used in birds should be ≤4 mg kg<sup>-1</sup>. In this study, 6 mg kg<sup>-1</sup> of lidocaine injected IV was not associated with adverse cardiovascular effects. These results suggest that the dose of 4 mg kg<sup>-1</sup> can be exceeded, at least in chickens, and opens the possibility of other therapeutic uses for lidocaine in birds.

Original languageEnglish (US)
Pages (from-to)442-448
Number of pages7
JournalVeterinary Anaesthesia and Analgesia
Volume42
Issue number4
DOIs
StatePublished - Jul 1 2015

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lidocaine
Isoflurane
isoflurane
Lidocaine
Chickens
broiler chickens
chickens
dosage
blood pressure
Blood Pressure
Birds
Ross (chicken breed)
heart rate
animals
Heart Rate
experimental design
birds
Therapeutic Uses
animal behavior
confidence interval

Keywords

  • Avian
  • Bird
  • Lidocaine
  • Local anesthesia
  • Ross-708
  • Toxicity

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Cardiovascular tolerance of intravenous lidocaine in broiler chickens (Gallus gallus domesticus) anesthetized with isoflurane. / Brandão, João; da Cunha, Anderson F.; Pypendop, Bruno H; Stout, Rhett; Nevarez, Javier; Tully, Thomas N.

In: Veterinary Anaesthesia and Analgesia, Vol. 42, No. 4, 01.07.2015, p. 442-448.

Research output: Contribution to journalArticle

Brandão, João ; da Cunha, Anderson F. ; Pypendop, Bruno H ; Stout, Rhett ; Nevarez, Javier ; Tully, Thomas N. / Cardiovascular tolerance of intravenous lidocaine in broiler chickens (Gallus gallus domesticus) anesthetized with isoflurane. In: Veterinary Anaesthesia and Analgesia. 2015 ; Vol. 42, No. 4. pp. 442-448.
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T1 - Cardiovascular tolerance of intravenous lidocaine in broiler chickens (Gallus gallus domesticus) anesthetized with isoflurane

AU - Brandão, João

AU - da Cunha, Anderson F.

AU - Pypendop, Bruno H

AU - Stout, Rhett

AU - Nevarez, Javier

AU - Tully, Thomas N.

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N2 - Objective: To determine the cardiovascular effects of lidocaine infused intravenously (IV) in broiler chickens. Study design: Two phase study: Phase 1, randomized up-and-down study to determine effective dose 50 (ED50) for lidocaine; Phase 2, prospective randomized study to determine the cardiovascular effects of lidocaine. Animals: Seventeen Ross-708 broiler chickens (Gallus gallus domesticus) [11 chickens (Phase 1) and 6 chickens (Phase 2)], weighing 2.6-4.3 kg. Methods: After induction of anesthesia with isoflurane and placement of monitoring equipment including invasive blood pressure, chickens were administered lidocaine IV. During Phase 1, using an up-and-down design, each animal received a variable dose selected based on the response of the previous animal. During Phase 2, each animal was administered 6 mg kg-1 of lidocaine IV over 2 minutes. Clinically irrelevant cardiovascular effects were defined as a relative decrease of heart rate (HR) and mean blood pressure (MAP) <30% subsequent to IV lidocaine administration. The ED50 was defined as the dose rate that would cause clinically irrelevant cardiovascular depression in 50% of the population. Results: During Phase 1, using an up-and-down study design (n = 11), the ED50 of lidocaine was determined to be 6.30 mg kg-1 and 6.22 mg kg-1 (95% confidence interval, 5.30-7.13 mg kg-1), when calculated by Dixon's up-and-down method, and logistic regression, respectively. During Phase 2, following infusion of lidocaine (6 mg kg-1), no clinically relevant effects on HR or MAP were detected in any animal. Conclusions and clinical relevance: Previous reports state that the dose of lidocaine used in birds should be ≤4 mg kg-1. In this study, 6 mg kg-1 of lidocaine injected IV was not associated with adverse cardiovascular effects. These results suggest that the dose of 4 mg kg-1 can be exceeded, at least in chickens, and opens the possibility of other therapeutic uses for lidocaine in birds.

AB - Objective: To determine the cardiovascular effects of lidocaine infused intravenously (IV) in broiler chickens. Study design: Two phase study: Phase 1, randomized up-and-down study to determine effective dose 50 (ED50) for lidocaine; Phase 2, prospective randomized study to determine the cardiovascular effects of lidocaine. Animals: Seventeen Ross-708 broiler chickens (Gallus gallus domesticus) [11 chickens (Phase 1) and 6 chickens (Phase 2)], weighing 2.6-4.3 kg. Methods: After induction of anesthesia with isoflurane and placement of monitoring equipment including invasive blood pressure, chickens were administered lidocaine IV. During Phase 1, using an up-and-down design, each animal received a variable dose selected based on the response of the previous animal. During Phase 2, each animal was administered 6 mg kg-1 of lidocaine IV over 2 minutes. Clinically irrelevant cardiovascular effects were defined as a relative decrease of heart rate (HR) and mean blood pressure (MAP) <30% subsequent to IV lidocaine administration. The ED50 was defined as the dose rate that would cause clinically irrelevant cardiovascular depression in 50% of the population. Results: During Phase 1, using an up-and-down study design (n = 11), the ED50 of lidocaine was determined to be 6.30 mg kg-1 and 6.22 mg kg-1 (95% confidence interval, 5.30-7.13 mg kg-1), when calculated by Dixon's up-and-down method, and logistic regression, respectively. During Phase 2, following infusion of lidocaine (6 mg kg-1), no clinically relevant effects on HR or MAP were detected in any animal. Conclusions and clinical relevance: Previous reports state that the dose of lidocaine used in birds should be ≤4 mg kg-1. In this study, 6 mg kg-1 of lidocaine injected IV was not associated with adverse cardiovascular effects. These results suggest that the dose of 4 mg kg-1 can be exceeded, at least in chickens, and opens the possibility of other therapeutic uses for lidocaine in birds.

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KW - Toxicity

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