Cardiovascular risks associated with low dose ionizing particle radiation

Xinhua Yan, Sharath P. Sasi, Hannah Gee, JuYong Lee, Yongyao Yang, Raman Mehrzad, Jillian Onufrak, Jin Song, Heiko Enderling, Akhil Agarwal, Layla Rahimi, James Morgan, Paul F. Wilson, Joseph Carrozza, Kenneth Walsh, Raj Kishore, David A. Goukassian

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Previous epidemiologic data demonstrate that cardiovascular (CV) morbidity and mortality may occur decades after ionizing radiation exposure. With increased use of proton and carbon ion radiotherapy and concerns about space radiation exposures to astronauts on future long-duration exploration-type missions, the long-term effects and risks of low-dose charged particle irradiation on the CV system must be better appreciated. Here we report on the long-term effects of wholebody proton (1H; 0.5 Gy, 1 GeV) and iron ion (56Fe; 0.15 Gy, 1GeV/nucleon) irradiation with and without an acute myocardial ischemia (AMI) event in mice. We show that cardiac function of proton-irradiated mice initially improves at 1 month but declines by 10 months post-irradiation. In AMI-induced mice, prior proton irradiation improved cardiac function restoration and enhanced cardiac remodeling. This was associated with increased pro-survival gene expression in cardiac tissues. In contrast, cardiac function was significantly declined in 56Fe ion-irradiated mice at 1 and 3 months but recovered at 10 months. In addition, 56Fe ion-irradiation led to poorer cardiac function and more adverse remodeling in AMI-induced mice, and was associated with decreased angiogenesis and pro-survival factors in cardiac tissues at any time point examined up to 10 months. This is the first study reporting CV effects following low dose proton and iron ion irradiation during normal aging and post-AMI. Understanding the biological effects of charged particle radiation qualities on the CV system is necessary both for the mitigation of space exploration CV risks and for understanding of long-term CV effects following charged particle radiotherapy.

Original languageEnglish (US)
Article numbere110269
JournalPLoS One
Volume9
Issue number10
DOIs
StatePublished - Oct 22 2014
Externally publishedYes

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Ionizing Radiation
ionization
Dosimetry
Protons
Charged particles
irradiation
protons
Myocardial Ischemia
cardiac output
myocardial ischemia
Radiation
Cardiovascular system
ions
Ions
Radiotherapy
Irradiation
dosage
Ion bombardment
mice
Cardiovascular System

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Yan, X., Sasi, S. P., Gee, H., Lee, J., Yang, Y., Mehrzad, R., ... Goukassian, D. A. (2014). Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One, 9(10), [e110269]. https://doi.org/10.1371/journal.pone.0110269

Cardiovascular risks associated with low dose ionizing particle radiation. / Yan, Xinhua; Sasi, Sharath P.; Gee, Hannah; Lee, JuYong; Yang, Yongyao; Mehrzad, Raman; Onufrak, Jillian; Song, Jin; Enderling, Heiko; Agarwal, Akhil; Rahimi, Layla; Morgan, James; Wilson, Paul F.; Carrozza, Joseph; Walsh, Kenneth; Kishore, Raj; Goukassian, David A.

In: PLoS One, Vol. 9, No. 10, e110269, 22.10.2014.

Research output: Contribution to journalArticle

Yan, X, Sasi, SP, Gee, H, Lee, J, Yang, Y, Mehrzad, R, Onufrak, J, Song, J, Enderling, H, Agarwal, A, Rahimi, L, Morgan, J, Wilson, PF, Carrozza, J, Walsh, K, Kishore, R & Goukassian, DA 2014, 'Cardiovascular risks associated with low dose ionizing particle radiation', PLoS One, vol. 9, no. 10, e110269. https://doi.org/10.1371/journal.pone.0110269
Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R et al. Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One. 2014 Oct 22;9(10). e110269. https://doi.org/10.1371/journal.pone.0110269
Yan, Xinhua ; Sasi, Sharath P. ; Gee, Hannah ; Lee, JuYong ; Yang, Yongyao ; Mehrzad, Raman ; Onufrak, Jillian ; Song, Jin ; Enderling, Heiko ; Agarwal, Akhil ; Rahimi, Layla ; Morgan, James ; Wilson, Paul F. ; Carrozza, Joseph ; Walsh, Kenneth ; Kishore, Raj ; Goukassian, David A. / Cardiovascular risks associated with low dose ionizing particle radiation. In: PLoS One. 2014 ; Vol. 9, No. 10.
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