Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes

Niklas Timby, Bo Lönnerdal, Olle Hernell, Magnus Domellöf

Research output: Contribution to journalArticle

30 Scopus citations


BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition.

METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age.

RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group.

CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalPediatric Research
Issue number4
StatePublished - Oct 1 2014


ASJC Scopus subject areas

  • Medicine(all)

Cite this