Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes

Niklas Timby, Bo Lönnerdal, Olle Hernell, Magnus Domellöf

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition.

METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age.

RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group.

CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalPediatric Research
Volume76
Issue number4
DOIs
StatePublished - Oct 1 2014

Fingerprint

Breast
Infant Formula
Membranes
HDL Lipoproteins
Serum
LDL Lipoproteins
Fats
Cholesterol
milk fat globule
Lipids
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes. / Timby, Niklas; Lönnerdal, Bo; Hernell, Olle; Domellöf, Magnus.

In: Pediatric Research, Vol. 76, No. 4, 01.10.2014, p. 394-400.

Research output: Contribution to journalArticle

Timby, Niklas ; Lönnerdal, Bo ; Hernell, Olle ; Domellöf, Magnus. / Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes. In: Pediatric Research. 2014 ; Vol. 76, No. 4. pp. 394-400.
@article{39b7d4f075334c749cafe10e407544cb,
title = "Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes",
abstract = "BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition.METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age.RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group.CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.",
author = "Niklas Timby and Bo L{\"o}nnerdal and Olle Hernell and Magnus Domell{\"o}f",
year = "2014",
month = "10",
day = "1",
doi = "10.1038/pr.2014.110",
language = "English (US)",
volume = "76",
pages = "394--400",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes

AU - Timby, Niklas

AU - Lönnerdal, Bo

AU - Hernell, Olle

AU - Domellöf, Magnus

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition.METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age.RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group.CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.

AB - BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition.METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age.RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group.CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.

UR - http://www.scopus.com/inward/record.url?scp=84926416650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926416650&partnerID=8YFLogxK

U2 - 10.1038/pr.2014.110

DO - 10.1038/pr.2014.110

M3 - Article

C2 - 25116230

AN - SCOPUS:84926416650

VL - 76

SP - 394

EP - 400

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 4

ER -