Cardiovascular, respiratory and metabolic responses to apnea induced by atlanto-occipital intrathecal lidocaine injection in anesthetized horses

Alonso Guedes, Monica R Aleman, Eric Davis, Caitlin Tearney

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To determine physiologic responses to apnea-induced severe hypoxemia in anesthetized horses. Study design: Prospective experimental study. Animals: Six university-owned horses with a median (range) body weight of 500 (220–510) kg and aged 13.5 (0.8–24.0) years scheduled for euthanasia. Methods: Xylazine–midazolam–ketamine-anesthetized horses breathing room air spontaneously were instrumented with a facial artery catheter for pressure measurement and blood sampling, and were made apneic with atlanto-occipital intrathecal lidocaine (4 mg kg−1). Cardiopulmonary, biochemical and hematologic variables were recorded before (baseline) and every minute for 10 minutes after lidocaine injection. Results: PaO2 values were: baseline, 55 mmHg (7.3 kPa); 1 minute, 28 mmHg (3.8 kPa); 2 minutes, 18 mmHg (2.4 kPa); 3 minutes, 15 mmHg (2.0 kPa), and 4–10 minutes, (8–11 mmHg (1.1–1.5 kPa). PaCO2 values were: baseline, 50 mmHg (6.7 kPa); 1 minute, 61 mmHg (8.1 kPa), and 2–10 minutes, 64–66 mmHg (8.5–8.8 kPa). Base excess values at baseline, 1 minute and 2–10 minutes were 5.3 mmol L−1, 6.5 mmol L−1 and 7.0–8.1 mmol L−1, respectively. Pulse rates at baseline, 1 minute and 2–7 minutes were 36, 53 and 54–85 beats minute−1, respectively. Asystole occurred at 8 minutes. Pulse pressures were 50 mmHg at baseline and 1 minute, and 39 mmHg, 31 mmHg, 22 mmHg, 17 mmHg and 1–9 mmHg at 2, 3, 4, 5 and 6–10 minutes, respectively. Lactate was 0.9 mmol L−1 at baseline, progressively increasing to 1.7–2.4 mmol L−1 at 7–10 minutes. Packed cell volume increased after 7 minutes of apnea. There were no other major changes. Conclusions and clinical relevance: Apnea immediately exacerbated hypoxemia and hypercapnia and rapidly caused hemodynamic instability. Apnea in hypoxemic anesthetized horses is associated with a serious risk for progress to cardiovascular collapse.

Original languageEnglish (US)
Pages (from-to)590-598
Number of pages9
JournalVeterinary Anaesthesia and Analgesia
Volume43
Issue number6
DOIs
StatePublished - Nov 1 2016

Keywords

  • heart rate
  • hypercapnia
  • hypotension
  • hypoxia
  • mortality

ASJC Scopus subject areas

  • veterinary(all)

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