Cardiovascular reflexes evoked by histamine stimulation of the stomach

Charles L Stebbins, S. J. Theodossy, J. C. Longhurst

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This study examined the potential for histamine to cause cardiovascular reflexes when applied to the serosal or mucosal surface of the stomach. Thus, in chloralose-anesthetized cats, histamine was applied to the serosal surface of the stomach in concentrations ranging from 0.5 to 1,000 μg/ml. This resulted in graded increases in mean arterial pressure (MAP), maximal left ventricular pressure over time (dP/dt), and heart rate ranging from 9 ± 4 to 30 ± 3 mmHg, 450 ± 103 to 1,710 ± 610 mmHg/s, and 2 ± 1 to 13 ± 4 beats/min, respectively. Histamine stimulation of the gastric serosa evoked a greater pressor response than that observed when the same concentration of histamine (100 μg/ml) was applied to the gastric mucosa (43 ± 7 vs. 13 ± 3 mmHg, respectively). In six cats, celiac ganglionectomy abolished the previously observed cardiovascular response to histamine stimulation of the serosal surface of the stomach. When the gastric serosa was treated with the H1-receptor antagonist diphenhydramine (1 mg/ml) (n = 5), the cardiovascular response to histamine was abolished. In five other cats, administration of the H2-antagonist ranitidine (1 mg/ml) had no effect on the histamine-induced responses. When indomethacin (2-5 mg/ml) was applied to the serosal surface of the stomach (n = 6), histamine-induced increases in MAP and dP/dt were attenuated. However, application of PGE2 (1 μg/ml) restored these two responses. These results suggest that histamine stimulates H1-receptors in the gastric wall to cause reflex cardiovascular responses that are dependent, in part, on the local production of prostaglandins.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume260
Issue number4 29/4
StatePublished - 1991

Keywords

  • Cats
  • Gastric smooth muscle contraction
  • H-receptors
  • Prostaglandins

ASJC Scopus subject areas

  • Physiology

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