Cardiovascular effects of venous air embolism during air and oxygen breathing

Eugene Steffey, G. E. Gauger, E. I. Eger

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

To determine if denitrogenation mitigates the cardiovascular effects of venous air emboli, air was infused intravenously in halothane anesthetized dogs breathing oxygen (O 2) or 75 to 79% nitrogen (N 2) (O 2 supplemented air). During a constant infusion rate of 3.5 or 7 ml./min. in 6 dogs, the volume of air required to produce a 40% decrease in mean arterial pressure (MAP) with O 2 breathing was double the volume required during air breathing. In 4 additional dogs, 3 ml./kg of air injected over 4 to 5 min. decreased MAP 35 to 40%, but breathing air or O 2 produced no difference in the spontaneous rate of return of MAP to 90% of control. The results indicate that when air slowly enters the venous circulation, larger volumes are necessary to produce cardiovascular depression in animals breathing O 2. However, there is no significant difference in the rate of cardiovascular recovery during air versus O 2 breathing once depression occurs.

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalAnesthesia and Analgesia
Volume53
Issue number4
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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