Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats

Bruno H Pypendop, Juhana Honkavaara, Jan Ilkiw

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats. Study design: Prospective Latin square experimental study. Animals: Six healthy adult purpose-bred cats. Methods: Cats were anesthetized with desflurane in oxygen for instrumentation with a carotid artery catheter and a thermodilution catheter in the pulmonary artery. One hour after discontinuation of desflurane, cats were administered dexmedetomidine (25 μg kg-1), MK-467 (600 μg kg-1), or dexmedetomidine (25 μg kg-1) and MK-467 (600 μg kg-1). All treatments were administered IV as a bolus. Cardiovascular variables were measured prior to drug administration and for 8 hours thereafter. Only data from the dexmedetomidine and dexmedetomidine-MK-467 treatments were analyzed. Results: Dexmedetomidine produced significant decreases in heart rate, cardiac index and right ventricular stroke work index, and significant increases in arterial blood pressure, central venous pressure, pulmonary artery pressure and systemic vascular resistance index. Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index. Conclusion and clinical relevance: Following IV co-administration, MK-467 effectively attenuated dexmedetomidine-induced cardiovascular effects in cats. The drug combination resulted in transient reduction in arterial blood pressure, without causing hypotension.

Original languageEnglish (US)
JournalVeterinary Anaesthesia and Analgesia
DOIs
StateAccepted/In press - 2016

Fingerprint

L 659066
dexmedetomidine
Dexmedetomidine
intravenous injection
Intravenous Administration
Cats
cats
blood pressure
pulmonary artery
stroke
catheters
Pulmonary Artery
Arterial Pressure
Catheters
Stroke
Thermodilution
combination drug therapy
Central Venous Pressure
carotid arteries
hypotension

Keywords

  • Antagonist
  • Cardiovascular
  • Cat
  • Dexmedetomidine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats",
abstract = "Objective: To characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats. Study design: Prospective Latin square experimental study. Animals: Six healthy adult purpose-bred cats. Methods: Cats were anesthetized with desflurane in oxygen for instrumentation with a carotid artery catheter and a thermodilution catheter in the pulmonary artery. One hour after discontinuation of desflurane, cats were administered dexmedetomidine (25 μg kg-1), MK-467 (600 μg kg-1), or dexmedetomidine (25 μg kg-1) and MK-467 (600 μg kg-1). All treatments were administered IV as a bolus. Cardiovascular variables were measured prior to drug administration and for 8 hours thereafter. Only data from the dexmedetomidine and dexmedetomidine-MK-467 treatments were analyzed. Results: Dexmedetomidine produced significant decreases in heart rate, cardiac index and right ventricular stroke work index, and significant increases in arterial blood pressure, central venous pressure, pulmonary artery pressure and systemic vascular resistance index. Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index. Conclusion and clinical relevance: Following IV co-administration, MK-467 effectively attenuated dexmedetomidine-induced cardiovascular effects in cats. The drug combination resulted in transient reduction in arterial blood pressure, without causing hypotension.",
keywords = "Antagonist, Cardiovascular, Cat, Dexmedetomidine",
author = "Pypendop, {Bruno H} and Juhana Honkavaara and Jan Ilkiw",
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doi = "10.1111/vaa.12397",
language = "English (US)",
journal = "Veterinary Anaesthesia and Analgesia",
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T1 - Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats

AU - Pypendop, Bruno H

AU - Honkavaara, Juhana

AU - Ilkiw, Jan

PY - 2016

Y1 - 2016

N2 - Objective: To characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats. Study design: Prospective Latin square experimental study. Animals: Six healthy adult purpose-bred cats. Methods: Cats were anesthetized with desflurane in oxygen for instrumentation with a carotid artery catheter and a thermodilution catheter in the pulmonary artery. One hour after discontinuation of desflurane, cats were administered dexmedetomidine (25 μg kg-1), MK-467 (600 μg kg-1), or dexmedetomidine (25 μg kg-1) and MK-467 (600 μg kg-1). All treatments were administered IV as a bolus. Cardiovascular variables were measured prior to drug administration and for 8 hours thereafter. Only data from the dexmedetomidine and dexmedetomidine-MK-467 treatments were analyzed. Results: Dexmedetomidine produced significant decreases in heart rate, cardiac index and right ventricular stroke work index, and significant increases in arterial blood pressure, central venous pressure, pulmonary artery pressure and systemic vascular resistance index. Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index. Conclusion and clinical relevance: Following IV co-administration, MK-467 effectively attenuated dexmedetomidine-induced cardiovascular effects in cats. The drug combination resulted in transient reduction in arterial blood pressure, without causing hypotension.

AB - Objective: To characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats. Study design: Prospective Latin square experimental study. Animals: Six healthy adult purpose-bred cats. Methods: Cats were anesthetized with desflurane in oxygen for instrumentation with a carotid artery catheter and a thermodilution catheter in the pulmonary artery. One hour after discontinuation of desflurane, cats were administered dexmedetomidine (25 μg kg-1), MK-467 (600 μg kg-1), or dexmedetomidine (25 μg kg-1) and MK-467 (600 μg kg-1). All treatments were administered IV as a bolus. Cardiovascular variables were measured prior to drug administration and for 8 hours thereafter. Only data from the dexmedetomidine and dexmedetomidine-MK-467 treatments were analyzed. Results: Dexmedetomidine produced significant decreases in heart rate, cardiac index and right ventricular stroke work index, and significant increases in arterial blood pressure, central venous pressure, pulmonary artery pressure and systemic vascular resistance index. Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index. Conclusion and clinical relevance: Following IV co-administration, MK-467 effectively attenuated dexmedetomidine-induced cardiovascular effects in cats. The drug combination resulted in transient reduction in arterial blood pressure, without causing hypotension.

KW - Antagonist

KW - Cardiovascular

KW - Cat

KW - Dexmedetomidine

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