Cardiovascular disease is the leading cause of death among endometrial cancer patients

Kristy K. Ward, Nina R. Shah, Cheryl C. Saenz, Michael T. McHale, Edwin A. Alvarez, Steven C. Plaxe

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: To evaluate the causes of death among women with endometrial cancer. Methods: SEER registries from 1973-1988 were queried to perform a retrospective cohort study of women with invasive epithelial endometrial cancer. Causes of death were compared according to grade and stage. Results: 33,232 women with incident cases of endometrial cancer had died at the time of last follow up. Overall, women were most likely to die from cardiovascular disease (35.9%, 95% CI 35.3-36.3%), followed by other causes, other malignancies, and endometrial cancer. Women with low grade localized cancer were most likely to die of cardiovascular disease, while women with high grade advanced cancer were least likely to die of cardiovascular disease and most likely to die of endometrial cancer. For the entire population, risk of death from cardiovascular causes surpasses the risk of death from endometrial cancer 5 years after diagnosis. Conclusions: Higher risk of cardiac death among endometrial cancer patients likely reflects the high probability of curative cancer treatment and the prevalence of cardiac disease and risk factors. As the probability of dying of endometrial cancer decreases with time, the probability of dying of cardiovascular disease increases. Interventions and investigations aimed at addressing risk factors for cardiovascular disease may have the greatest potential to improve survival for women diagnosed with endometrial cancer and should feature prominently in treatment and survivorship plans.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalGynecologic Oncology
Volume126
Issue number2
DOIs
StatePublished - Aug 2012

Fingerprint

Endometrial Neoplasms
Cause of Death
Cardiovascular Diseases
Neoplasms
Registries
Heart Diseases
Cohort Studies
Survival Rate
Retrospective Studies
Survival
Therapeutics

Keywords

  • Cancer
  • Cardiovascular
  • Endometrial
  • Survivor
  • Uterine

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Ward, K. K., Shah, N. R., Saenz, C. C., McHale, M. T., Alvarez, E. A., & Plaxe, S. C. (2012). Cardiovascular disease is the leading cause of death among endometrial cancer patients. Gynecologic Oncology, 126(2), 176-179. https://doi.org/10.1016/j.ygyno.2012.04.013

Cardiovascular disease is the leading cause of death among endometrial cancer patients. / Ward, Kristy K.; Shah, Nina R.; Saenz, Cheryl C.; McHale, Michael T.; Alvarez, Edwin A.; Plaxe, Steven C.

In: Gynecologic Oncology, Vol. 126, No. 2, 08.2012, p. 176-179.

Research output: Contribution to journalArticle

Ward, KK, Shah, NR, Saenz, CC, McHale, MT, Alvarez, EA & Plaxe, SC 2012, 'Cardiovascular disease is the leading cause of death among endometrial cancer patients', Gynecologic Oncology, vol. 126, no. 2, pp. 176-179. https://doi.org/10.1016/j.ygyno.2012.04.013
Ward, Kristy K. ; Shah, Nina R. ; Saenz, Cheryl C. ; McHale, Michael T. ; Alvarez, Edwin A. ; Plaxe, Steven C. / Cardiovascular disease is the leading cause of death among endometrial cancer patients. In: Gynecologic Oncology. 2012 ; Vol. 126, No. 2. pp. 176-179.
@article{58a04fedd74940138715e20a95e6c974,
title = "Cardiovascular disease is the leading cause of death among endometrial cancer patients",
abstract = "Objective: To evaluate the causes of death among women with endometrial cancer. Methods: SEER registries from 1973-1988 were queried to perform a retrospective cohort study of women with invasive epithelial endometrial cancer. Causes of death were compared according to grade and stage. Results: 33,232 women with incident cases of endometrial cancer had died at the time of last follow up. Overall, women were most likely to die from cardiovascular disease (35.9{\%}, 95{\%} CI 35.3-36.3{\%}), followed by other causes, other malignancies, and endometrial cancer. Women with low grade localized cancer were most likely to die of cardiovascular disease, while women with high grade advanced cancer were least likely to die of cardiovascular disease and most likely to die of endometrial cancer. For the entire population, risk of death from cardiovascular causes surpasses the risk of death from endometrial cancer 5 years after diagnosis. Conclusions: Higher risk of cardiac death among endometrial cancer patients likely reflects the high probability of curative cancer treatment and the prevalence of cardiac disease and risk factors. As the probability of dying of endometrial cancer decreases with time, the probability of dying of cardiovascular disease increases. Interventions and investigations aimed at addressing risk factors for cardiovascular disease may have the greatest potential to improve survival for women diagnosed with endometrial cancer and should feature prominently in treatment and survivorship plans.",
keywords = "Cancer, Cardiovascular, Endometrial, Survivor, Uterine",
author = "Ward, {Kristy K.} and Shah, {Nina R.} and Saenz, {Cheryl C.} and McHale, {Michael T.} and Alvarez, {Edwin A.} and Plaxe, {Steven C.}",
year = "2012",
month = "8",
doi = "10.1016/j.ygyno.2012.04.013",
language = "English (US)",
volume = "126",
pages = "176--179",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Cardiovascular disease is the leading cause of death among endometrial cancer patients

AU - Ward, Kristy K.

AU - Shah, Nina R.

AU - Saenz, Cheryl C.

AU - McHale, Michael T.

AU - Alvarez, Edwin A.

AU - Plaxe, Steven C.

PY - 2012/8

Y1 - 2012/8

N2 - Objective: To evaluate the causes of death among women with endometrial cancer. Methods: SEER registries from 1973-1988 were queried to perform a retrospective cohort study of women with invasive epithelial endometrial cancer. Causes of death were compared according to grade and stage. Results: 33,232 women with incident cases of endometrial cancer had died at the time of last follow up. Overall, women were most likely to die from cardiovascular disease (35.9%, 95% CI 35.3-36.3%), followed by other causes, other malignancies, and endometrial cancer. Women with low grade localized cancer were most likely to die of cardiovascular disease, while women with high grade advanced cancer were least likely to die of cardiovascular disease and most likely to die of endometrial cancer. For the entire population, risk of death from cardiovascular causes surpasses the risk of death from endometrial cancer 5 years after diagnosis. Conclusions: Higher risk of cardiac death among endometrial cancer patients likely reflects the high probability of curative cancer treatment and the prevalence of cardiac disease and risk factors. As the probability of dying of endometrial cancer decreases with time, the probability of dying of cardiovascular disease increases. Interventions and investigations aimed at addressing risk factors for cardiovascular disease may have the greatest potential to improve survival for women diagnosed with endometrial cancer and should feature prominently in treatment and survivorship plans.

AB - Objective: To evaluate the causes of death among women with endometrial cancer. Methods: SEER registries from 1973-1988 were queried to perform a retrospective cohort study of women with invasive epithelial endometrial cancer. Causes of death were compared according to grade and stage. Results: 33,232 women with incident cases of endometrial cancer had died at the time of last follow up. Overall, women were most likely to die from cardiovascular disease (35.9%, 95% CI 35.3-36.3%), followed by other causes, other malignancies, and endometrial cancer. Women with low grade localized cancer were most likely to die of cardiovascular disease, while women with high grade advanced cancer were least likely to die of cardiovascular disease and most likely to die of endometrial cancer. For the entire population, risk of death from cardiovascular causes surpasses the risk of death from endometrial cancer 5 years after diagnosis. Conclusions: Higher risk of cardiac death among endometrial cancer patients likely reflects the high probability of curative cancer treatment and the prevalence of cardiac disease and risk factors. As the probability of dying of endometrial cancer decreases with time, the probability of dying of cardiovascular disease increases. Interventions and investigations aimed at addressing risk factors for cardiovascular disease may have the greatest potential to improve survival for women diagnosed with endometrial cancer and should feature prominently in treatment and survivorship plans.

KW - Cancer

KW - Cardiovascular

KW - Endometrial

KW - Survivor

KW - Uterine

UR - http://www.scopus.com/inward/record.url?scp=84862881737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862881737&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2012.04.013

DO - 10.1016/j.ygyno.2012.04.013

M3 - Article

C2 - 22507532

AN - SCOPUS:84862881737

VL - 126

SP - 176

EP - 179

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -