Abstract
Circulatory and respiratory effects of intravenously administered acetylpromazine (0.033 and 0.067 mg/kg) and xylazine (0.5 and 1.0 mg/kg) were studied in drug cross-over fashion in eight laterally recumbent horses anesthetized only with halothane (1.06%, end-tidal) in O2. Both doses of acetylpromazine caused a significant and sustained elevation in cardiac output via a rise in stroke volume. Xylazine produced an initial significant fall in cardiac output followed by a return to control levels. Halothane anesthesia did not prevent xylazine-related atrioventricular conduction block. All treatments caused a similar significant fall in arterial blood pressure (acetylpromazine, total peripheral resistance-related; xylazine, cardiac output-related). PaCO2 significantly increased after all treatments. PaCO2 decreased significantly only following xylazine treatment. One horse (not included in the tabulation) developed ventricular fibrillation and died 15 min after receiving its first injection (0.5 mg/kg) of xylazine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 290-302 |
| Number of pages | 13 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 8 |
| Issue number | 3 |
| State | Published - Sep 1985 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Cardiovascular and respiratory effects of acetylpromazine and xylazine on halothane-anesthetized horses. / Steffey, Eugene; Kelly, A. B.; Farver, Thomas B; Woliner, M. J.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 8, No. 3, 09.1985, p. 290-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular and respiratory effects of acetylpromazine and xylazine on halothane-anesthetized horses.
AU - Steffey, Eugene
AU - Kelly, A. B.
AU - Farver, Thomas B
AU - Woliner, M. J.
PY - 1985/9
Y1 - 1985/9
N2 - Circulatory and respiratory effects of intravenously administered acetylpromazine (0.033 and 0.067 mg/kg) and xylazine (0.5 and 1.0 mg/kg) were studied in drug cross-over fashion in eight laterally recumbent horses anesthetized only with halothane (1.06%, end-tidal) in O2. Both doses of acetylpromazine caused a significant and sustained elevation in cardiac output via a rise in stroke volume. Xylazine produced an initial significant fall in cardiac output followed by a return to control levels. Halothane anesthesia did not prevent xylazine-related atrioventricular conduction block. All treatments caused a similar significant fall in arterial blood pressure (acetylpromazine, total peripheral resistance-related; xylazine, cardiac output-related). PaCO2 significantly increased after all treatments. PaCO2 decreased significantly only following xylazine treatment. One horse (not included in the tabulation) developed ventricular fibrillation and died 15 min after receiving its first injection (0.5 mg/kg) of xylazine.
AB - Circulatory and respiratory effects of intravenously administered acetylpromazine (0.033 and 0.067 mg/kg) and xylazine (0.5 and 1.0 mg/kg) were studied in drug cross-over fashion in eight laterally recumbent horses anesthetized only with halothane (1.06%, end-tidal) in O2. Both doses of acetylpromazine caused a significant and sustained elevation in cardiac output via a rise in stroke volume. Xylazine produced an initial significant fall in cardiac output followed by a return to control levels. Halothane anesthesia did not prevent xylazine-related atrioventricular conduction block. All treatments caused a similar significant fall in arterial blood pressure (acetylpromazine, total peripheral resistance-related; xylazine, cardiac output-related). PaCO2 significantly increased after all treatments. PaCO2 decreased significantly only following xylazine treatment. One horse (not included in the tabulation) developed ventricular fibrillation and died 15 min after receiving its first injection (0.5 mg/kg) of xylazine.
UR - http://www.scopus.com/inward/record.url?scp=0022120691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022120691&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 290
EP - 302
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 3
ER -