Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases

M. W. Roberts, K. A. Mathiesen, Hung S Ho, B. M. Wolfe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Carbon dioxide is the current gas of choice for pneumoperitoneum, but hemodynamic and acid-base effects secondary to its systemic absorption have been reported. Various studies have suggested inert gases as alternatives. Methods: We studied the cardiopulmonary responses to intravenous infusion of carbon dioxide, nitrous oxide, argon, helium, and nitrogen in anesthetized swine. The gas was infused into the femoral vein at a rate of 0.1 ml · kg-1 · min-1 for 30 min. The changes in end-tidal CO2, mean arterial pressure, hemodynamics, and arterial blood gases were compared to baseline values. Results: No animals died during infusion of the soluble gases (CO2 and N2O). Three of the five pigs infused with nitrogen died suddenly at 20 and 30 min of infusion. The animals in the insoluble gas groups (Ar, He, N2) experienced clinical pulmonary gas embolism and severe acidemia, hypercapnea and tachycardia. Conclusions: Venous gas embolism is poorly tolerated when the gas is relatively insoluble. Insoluble gases should not be used for pneumoperitoneum when there is any risk of venous gas embolism.

Original languageEnglish (US)
Pages (from-to)341-346
Number of pages6
JournalSurgical Endoscopy
Volume11
Issue number4
StatePublished - Apr 1997

Fingerprint

Intravenous Infusions
Gases
Air Embolism
Pneumoperitoneum
Carbon Dioxide
Nitrogen
Swine
Hemodynamics
Noble Gases
Helium
Femoral Vein
Argon
Nitrous Oxide
Pulmonary Embolism
Tachycardia
Arterial Pressure
Acids

Keywords

  • Inert gas
  • Laparoscopy
  • Venous gas embolism

ASJC Scopus subject areas

  • Surgery

Cite this

Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases. / Roberts, M. W.; Mathiesen, K. A.; Ho, Hung S; Wolfe, B. M.

In: Surgical Endoscopy, Vol. 11, No. 4, 04.1997, p. 341-346.

Research output: Contribution to journalArticle

Roberts, MW, Mathiesen, KA, Ho, HS & Wolfe, BM 1997, 'Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases', Surgical Endoscopy, vol. 11, no. 4, pp. 341-346.
Roberts, M. W. ; Mathiesen, K. A. ; Ho, Hung S ; Wolfe, B. M. / Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases. In: Surgical Endoscopy. 1997 ; Vol. 11, No. 4. pp. 341-346.
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