Cardiopulmonary responses to experimental venous carbon dioxide embolism

Kathrin L Troppmann, Hung S Ho, K. A. Mathiesen, B. M. Wolfe

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Although the low-flow CO2 insufflation rate used to initiate pneumoperitoneum may reduce the severity of potential venous embolism, its safety is not established. Methods: Anesthetized pigs were ventilated with room air at a fixed minute ventilation. After 1 h of baseline, they were intravenously infused with CO2 at the rate of 0.3, 0.75, or 1.2 ml/kg/min for 2 h (n = 5 for each group), followed by 1 h of recovery. Results: All animals experienced pulmonary hypertension, depressed stroke volume, hypoxemia, hypercarbia, and acidemia during intravenous CO2 infusion. They had systemic hypertension at the low rate and hypotension at the highest rate of infusion. End-tidal CO2 levels briefly decreased, then increased in all cases. In the highest rate group, three of the five animals (60%) died at 50, 65, and 100 min of infusion. These three animals had severe hypotension and hypoxemia, with visible coronary gas embolism. There was no patent foramen ovale at necropsy in any animals. Conclusions: The low-flow insufflation rate exceeds the fatal rate of continuous intravenous CO2 infusion. End-tidal CO2 levels were increased in venous CO2 embolism, not decreased as seen in venous air embolism. Severe hypoxemia and hypotension are predictors of potentially fatal cases.

Original languageEnglish (US)
Pages (from-to)1025-1030
Number of pages6
JournalSurgical Endoscopy
Volume12
Issue number8
StatePublished - Aug 1998

Fingerprint

Embolism
Carbon Dioxide
Hypotension
Air Embolism
Insufflation
Intravenous Infusions
Patent Foramen Ovale
Pneumoperitoneum
Hypercapnia
Pulmonary Hypertension
Stroke Volume
Ventilation
Swine
Air
Hypertension
Safety
Hypoxia

Keywords

  • Hypotension
  • Hypoxemia
  • Laparoscopy
  • Venous CO embolism

ASJC Scopus subject areas

  • Surgery

Cite this

Cardiopulmonary responses to experimental venous carbon dioxide embolism. / Troppmann, Kathrin L; Ho, Hung S; Mathiesen, K. A.; Wolfe, B. M.

In: Surgical Endoscopy, Vol. 12, No. 8, 08.1998, p. 1025-1030.

Research output: Contribution to journalArticle

Troppmann, Kathrin L ; Ho, Hung S ; Mathiesen, K. A. ; Wolfe, B. M. / Cardiopulmonary responses to experimental venous carbon dioxide embolism. In: Surgical Endoscopy. 1998 ; Vol. 12, No. 8. pp. 1025-1030.
@article{48b18cb8d0a24e6e986d54223a2b80b0,
title = "Cardiopulmonary responses to experimental venous carbon dioxide embolism",
abstract = "Background: Although the low-flow CO2 insufflation rate used to initiate pneumoperitoneum may reduce the severity of potential venous embolism, its safety is not established. Methods: Anesthetized pigs were ventilated with room air at a fixed minute ventilation. After 1 h of baseline, they were intravenously infused with CO2 at the rate of 0.3, 0.75, or 1.2 ml/kg/min for 2 h (n = 5 for each group), followed by 1 h of recovery. Results: All animals experienced pulmonary hypertension, depressed stroke volume, hypoxemia, hypercarbia, and acidemia during intravenous CO2 infusion. They had systemic hypertension at the low rate and hypotension at the highest rate of infusion. End-tidal CO2 levels briefly decreased, then increased in all cases. In the highest rate group, three of the five animals (60{\%}) died at 50, 65, and 100 min of infusion. These three animals had severe hypotension and hypoxemia, with visible coronary gas embolism. There was no patent foramen ovale at necropsy in any animals. Conclusions: The low-flow insufflation rate exceeds the fatal rate of continuous intravenous CO2 infusion. End-tidal CO2 levels were increased in venous CO2 embolism, not decreased as seen in venous air embolism. Severe hypoxemia and hypotension are predictors of potentially fatal cases.",
keywords = "Hypotension, Hypoxemia, Laparoscopy, Venous CO embolism",
author = "Troppmann, {Kathrin L} and Ho, {Hung S} and Mathiesen, {K. A.} and Wolfe, {B. M.}",
year = "1998",
month = "8",
language = "English (US)",
volume = "12",
pages = "1025--1030",
journal = "Surgical Endoscopy and Other Interventional Techniques",
issn = "0930-2794",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Cardiopulmonary responses to experimental venous carbon dioxide embolism

AU - Troppmann, Kathrin L

AU - Ho, Hung S

AU - Mathiesen, K. A.

AU - Wolfe, B. M.

PY - 1998/8

Y1 - 1998/8

N2 - Background: Although the low-flow CO2 insufflation rate used to initiate pneumoperitoneum may reduce the severity of potential venous embolism, its safety is not established. Methods: Anesthetized pigs were ventilated with room air at a fixed minute ventilation. After 1 h of baseline, they were intravenously infused with CO2 at the rate of 0.3, 0.75, or 1.2 ml/kg/min for 2 h (n = 5 for each group), followed by 1 h of recovery. Results: All animals experienced pulmonary hypertension, depressed stroke volume, hypoxemia, hypercarbia, and acidemia during intravenous CO2 infusion. They had systemic hypertension at the low rate and hypotension at the highest rate of infusion. End-tidal CO2 levels briefly decreased, then increased in all cases. In the highest rate group, three of the five animals (60%) died at 50, 65, and 100 min of infusion. These three animals had severe hypotension and hypoxemia, with visible coronary gas embolism. There was no patent foramen ovale at necropsy in any animals. Conclusions: The low-flow insufflation rate exceeds the fatal rate of continuous intravenous CO2 infusion. End-tidal CO2 levels were increased in venous CO2 embolism, not decreased as seen in venous air embolism. Severe hypoxemia and hypotension are predictors of potentially fatal cases.

AB - Background: Although the low-flow CO2 insufflation rate used to initiate pneumoperitoneum may reduce the severity of potential venous embolism, its safety is not established. Methods: Anesthetized pigs were ventilated with room air at a fixed minute ventilation. After 1 h of baseline, they were intravenously infused with CO2 at the rate of 0.3, 0.75, or 1.2 ml/kg/min for 2 h (n = 5 for each group), followed by 1 h of recovery. Results: All animals experienced pulmonary hypertension, depressed stroke volume, hypoxemia, hypercarbia, and acidemia during intravenous CO2 infusion. They had systemic hypertension at the low rate and hypotension at the highest rate of infusion. End-tidal CO2 levels briefly decreased, then increased in all cases. In the highest rate group, three of the five animals (60%) died at 50, 65, and 100 min of infusion. These three animals had severe hypotension and hypoxemia, with visible coronary gas embolism. There was no patent foramen ovale at necropsy in any animals. Conclusions: The low-flow insufflation rate exceeds the fatal rate of continuous intravenous CO2 infusion. End-tidal CO2 levels were increased in venous CO2 embolism, not decreased as seen in venous air embolism. Severe hypoxemia and hypotension are predictors of potentially fatal cases.

KW - Hypotension

KW - Hypoxemia

KW - Laparoscopy

KW - Venous CO embolism

UR - http://www.scopus.com/inward/record.url?scp=0032133808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032133808&partnerID=8YFLogxK

M3 - Article

C2 - 9685535

AN - SCOPUS:0032133808

VL - 12

SP - 1025

EP - 1030

JO - Surgical Endoscopy and Other Interventional Techniques

JF - Surgical Endoscopy and Other Interventional Techniques

SN - 0930-2794

IS - 8

ER -