Cardiopulmonary function during 5 hours of constant‐dose isoflurane in laterally recumbent, spontaneously breathing horses

Eugene Steffey, D. S. HODGSON, C. I. DUNLOP., M. F. MILLER, M. J. WOLINER, R. B. HEATH, J. GRANDY

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Steffey, E.P., Hodgson, D.S., Dunlop, C.I., Miller, M.F., Woliner, M.J., Heath, R.B. & Grandy, J. Cardiopulmonary function during 5 hours of constant‐dose isoflurane in laterally recumbent, spontaneously breathing horses. J. vet. Pharmacol. Therap. 10, 290–297. Hemodynamic and respiratory effects of 5 h of unvarying 1.57%, end‐tidal (1.2 MAC) isoflurane in O2 anesthesia were characterized in ten left laterally recumbent horses. Compared to base line values at 30 min of constant dose isoflurane, cardiac output, hematocrit, total plasma solids, PaC02, and peak inspired gas flow progressively and significantly (P < 0.05) increased over the course of study. Arterial blood pressure increased (P < 0.05) during the first 2 h of constant dose of isoflurane then decreased and remained near base line values. Inspiratory time progressively decreased with time of anesthesia. All horses recovered from anesthesia uneventfully within 1 h of termination of isoflurane.

Original languageEnglish (US)
Pages (from-to)290-297
Number of pages8
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Isoflurane
isoflurane
Horses
breathing
Respiration
horses
anesthesia
Anesthesia
cardiac output
hemodynamics
dosage
Hematocrit
Cardiac Output
hematocrit
blood pressure
Arterial Pressure
Gases
Hemodynamics
gases

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Cardiopulmonary function during 5 hours of constant‐dose isoflurane in laterally recumbent, spontaneously breathing horses. / Steffey, Eugene; HODGSON, D. S.; DUNLOP., C. I.; MILLER, M. F.; WOLINER, M. J.; HEATH, R. B.; GRANDY, J.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 10, No. 4, 01.01.1987, p. 290-297.

Research output: Contribution to journalArticle

Steffey, Eugene ; HODGSON, D. S. ; DUNLOP., C. I. ; MILLER, M. F. ; WOLINER, M. J. ; HEATH, R. B. ; GRANDY, J. / Cardiopulmonary function during 5 hours of constant‐dose isoflurane in laterally recumbent, spontaneously breathing horses. In: Journal of Veterinary Pharmacology and Therapeutics. 1987 ; Vol. 10, No. 4. pp. 290-297.
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