Cardiopulmonary effects of butorphanol in sevoflurane-anesthetized guineafowl (Numida meleagris)

André Escobar, Carlos A A Valadão, Robert J Brosnan, Fabíola N. Flôres, Maristela C S Lopes, Fábio N. Gava

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the cardiopulmonary changes induced by intravenous butorphanol administration in guineafowl anesthetized with sevoflurane. Study design: Prospective experimental trial. Animals: Eight adult guineafowl (Numida meleagris) weighing 1.61 ± 0.49 kg were used for the study. Methods: Birds were anesthetized with sevoflurane and allowed to breathe spontaneously. After endotracheal intubation, end-tidal sevoflurane was adjusted to 1.0 individual sevoflurane MAC that was previously determined in triplicate using a standard bracketing technique. The brachial artery was catheterized for direct pressure measurement and blood sampling. Heart rate and rhythm were monitored by electrocardiography and respiratory rate was recorded. Baseline data were recorded 30 minutes after induction. Then, end-tidal sevoflurane was adjusted to 0.8 individual MAC and after 15 minutes physiologic variables were measured again. Subsequently, butorphanol (4 mg kg-1) was administered intravenously over 10 seconds and physiologic responses were recorded at 1, 5, 10, 15, 20, 30 and 45 minutes after administration. Results: Butorphanol administration was associated with arrhythmias in all birds, including second-degree atrioventricular block, sinus arrest, ventricular and supraventricular tachycardia and ventricular premature complexes. Heart rate and arterial blood pressures decreased significantly 1 minute after butorphanol administration. Two birds developed severe hypotension, apnea and ventricular fibrillation 5 minutes after administration, and one died. Conclusions and clinical relevance: The butorphanol dose (4 mg kg-1) that produces clinically relevant sevoflurane MAC reduction in guineafowl caused severe adverse cardiopulmonary effects in two birds and was considered unsafe under the conditions used in this study.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalVeterinary Anaesthesia and Analgesia
Volume41
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Butorphanol
guineafowl
butorphanol
Birds
birds
heart rate
apnea
Heart Rate
Sinus Tachycardia
hypotension
electrocardiography
arrhythmia
blood sampling
respiratory rate
sinuses
Supraventricular Tachycardia
Intratracheal Intubation
Ventricular Premature Complexes
Brachial Artery
Atrioventricular Block

Keywords

  • Anesthesia
  • Birds
  • Butorphanol
  • Cardiac arrhythmias
  • Monitoring
  • Sevoflurane

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Cardiopulmonary effects of butorphanol in sevoflurane-anesthetized guineafowl (Numida meleagris). / Escobar, André; Valadão, Carlos A A; Brosnan, Robert J; Flôres, Fabíola N.; Lopes, Maristela C S; Gava, Fábio N.

In: Veterinary Anaesthesia and Analgesia, Vol. 41, No. 3, 2014, p. 284-289.

Research output: Contribution to journalArticle

Escobar, André ; Valadão, Carlos A A ; Brosnan, Robert J ; Flôres, Fabíola N. ; Lopes, Maristela C S ; Gava, Fábio N. / Cardiopulmonary effects of butorphanol in sevoflurane-anesthetized guineafowl (Numida meleagris). In: Veterinary Anaesthesia and Analgesia. 2014 ; Vol. 41, No. 3. pp. 284-289.
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abstract = "Objective: To evaluate the cardiopulmonary changes induced by intravenous butorphanol administration in guineafowl anesthetized with sevoflurane. Study design: Prospective experimental trial. Animals: Eight adult guineafowl (Numida meleagris) weighing 1.61 ± 0.49 kg were used for the study. Methods: Birds were anesthetized with sevoflurane and allowed to breathe spontaneously. After endotracheal intubation, end-tidal sevoflurane was adjusted to 1.0 individual sevoflurane MAC that was previously determined in triplicate using a standard bracketing technique. The brachial artery was catheterized for direct pressure measurement and blood sampling. Heart rate and rhythm were monitored by electrocardiography and respiratory rate was recorded. Baseline data were recorded 30 minutes after induction. Then, end-tidal sevoflurane was adjusted to 0.8 individual MAC and after 15 minutes physiologic variables were measured again. Subsequently, butorphanol (4 mg kg-1) was administered intravenously over 10 seconds and physiologic responses were recorded at 1, 5, 10, 15, 20, 30 and 45 minutes after administration. Results: Butorphanol administration was associated with arrhythmias in all birds, including second-degree atrioventricular block, sinus arrest, ventricular and supraventricular tachycardia and ventricular premature complexes. Heart rate and arterial blood pressures decreased significantly 1 minute after butorphanol administration. Two birds developed severe hypotension, apnea and ventricular fibrillation 5 minutes after administration, and one died. Conclusions and clinical relevance: The butorphanol dose (4 mg kg-1) that produces clinically relevant sevoflurane MAC reduction in guineafowl caused severe adverse cardiopulmonary effects in two birds and was considered unsafe under the conditions used in this study.",
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T1 - Cardiopulmonary effects of butorphanol in sevoflurane-anesthetized guineafowl (Numida meleagris)

AU - Escobar, André

AU - Valadão, Carlos A A

AU - Brosnan, Robert J

AU - Flôres, Fabíola N.

AU - Lopes, Maristela C S

AU - Gava, Fábio N.

PY - 2014

Y1 - 2014

N2 - Objective: To evaluate the cardiopulmonary changes induced by intravenous butorphanol administration in guineafowl anesthetized with sevoflurane. Study design: Prospective experimental trial. Animals: Eight adult guineafowl (Numida meleagris) weighing 1.61 ± 0.49 kg were used for the study. Methods: Birds were anesthetized with sevoflurane and allowed to breathe spontaneously. After endotracheal intubation, end-tidal sevoflurane was adjusted to 1.0 individual sevoflurane MAC that was previously determined in triplicate using a standard bracketing technique. The brachial artery was catheterized for direct pressure measurement and blood sampling. Heart rate and rhythm were monitored by electrocardiography and respiratory rate was recorded. Baseline data were recorded 30 minutes after induction. Then, end-tidal sevoflurane was adjusted to 0.8 individual MAC and after 15 minutes physiologic variables were measured again. Subsequently, butorphanol (4 mg kg-1) was administered intravenously over 10 seconds and physiologic responses were recorded at 1, 5, 10, 15, 20, 30 and 45 minutes after administration. Results: Butorphanol administration was associated with arrhythmias in all birds, including second-degree atrioventricular block, sinus arrest, ventricular and supraventricular tachycardia and ventricular premature complexes. Heart rate and arterial blood pressures decreased significantly 1 minute after butorphanol administration. Two birds developed severe hypotension, apnea and ventricular fibrillation 5 minutes after administration, and one died. Conclusions and clinical relevance: The butorphanol dose (4 mg kg-1) that produces clinically relevant sevoflurane MAC reduction in guineafowl caused severe adverse cardiopulmonary effects in two birds and was considered unsafe under the conditions used in this study.

AB - Objective: To evaluate the cardiopulmonary changes induced by intravenous butorphanol administration in guineafowl anesthetized with sevoflurane. Study design: Prospective experimental trial. Animals: Eight adult guineafowl (Numida meleagris) weighing 1.61 ± 0.49 kg were used for the study. Methods: Birds were anesthetized with sevoflurane and allowed to breathe spontaneously. After endotracheal intubation, end-tidal sevoflurane was adjusted to 1.0 individual sevoflurane MAC that was previously determined in triplicate using a standard bracketing technique. The brachial artery was catheterized for direct pressure measurement and blood sampling. Heart rate and rhythm were monitored by electrocardiography and respiratory rate was recorded. Baseline data were recorded 30 minutes after induction. Then, end-tidal sevoflurane was adjusted to 0.8 individual MAC and after 15 minutes physiologic variables were measured again. Subsequently, butorphanol (4 mg kg-1) was administered intravenously over 10 seconds and physiologic responses were recorded at 1, 5, 10, 15, 20, 30 and 45 minutes after administration. Results: Butorphanol administration was associated with arrhythmias in all birds, including second-degree atrioventricular block, sinus arrest, ventricular and supraventricular tachycardia and ventricular premature complexes. Heart rate and arterial blood pressures decreased significantly 1 minute after butorphanol administration. Two birds developed severe hypotension, apnea and ventricular fibrillation 5 minutes after administration, and one died. Conclusions and clinical relevance: The butorphanol dose (4 mg kg-1) that produces clinically relevant sevoflurane MAC reduction in guineafowl caused severe adverse cardiopulmonary effects in two birds and was considered unsafe under the conditions used in this study.

KW - Anesthesia

KW - Birds

KW - Butorphanol

KW - Cardiac arrhythmias

KW - Monitoring

KW - Sevoflurane

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