Cardiocirculatory and myocardial energetic effects of prostaglandin E1 in severe left ventricular failure due to chronic coronary heart disease

Najam A. Awan, Mark K. Evenson, Kathleen E. Needham, James M. Beattie, Ezra A Amsterdam, Dean T. Mason

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The cardiocirculatory actions of brief (69 ± 5 minutes) infusions of prostaglandin E1 were evaluated in nine chronic coronary heart disease patients with severe left ventricular (LV) failure caused by previous myocardial infarction. Prostaglandin E1 infusion did not alter heart rate (HR) and produced modest declines in mean systemic blood pressure (BP) (85 ± 6 to 76 ± 5 mm Hg, p < 0.025) and LV filling pressure (19 ± 3 to 15 ± 2 mm Hg, p < 0.01). Simultaneously, prostaglandin E1 augmented LV pump function raising cardiac index from 1.9 ± 0.2 to 2.5 ± 0.2 L/min/m2 (p < 0.005), elevating stroke index from 28 ± 2.4 to 35 ± 2.9 ml/beat/m2 (p < 0.01), and increasing stroke work index from 26 ± 4.3 to 30 ± 4.4 gm·m/m2 (p < 0.02). Additionally, total systemic vascular resistance decreased from 1862 ± 192 to 1282 ± 100 dynes-sec-cm-5 (p < 0.02) and double product LV aerobic index of HR · systolic BP diminished from 9492 ± 666 to 8278 ± 493 (p < 0.02). Concomitantly, in the forearm, vascular resistance fell, blood flow rose, and venous tone remained unchanged. These results indicate that prostaglandin E1 is a potent systemic arteriolar dilator with markedly beneficial effects on cardiac function in chronic coronary patients having severe ischemic LV failure refractory to conventional therapy.

Original languageEnglish (US)
Pages (from-to)703-709
Number of pages7
JournalAmerican Heart Journal
Issue number4
StatePublished - 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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