Cardiocirculatory actions of trimazosin and sodium nitroprusside in ischemic heart disease

Najam A. Awan, John Hermanovich, Zakauddin Vera, Ezra A Amsterdam, Dean T. Mason

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although postload-reducing drugs are effective vasodilators in chronic congestive heart failure, the clinical application of the approach to ambulatory patient management remains difficult. We compared the hemodynamic effects of the new oral systemic vasodilator trimazosin (TZ) with those of nitroprusside (NP). Both TZ (172 mg) and NP (46 μg/min) decreased mean blood pressure modestly (P < 0.001), while causing considerable decline in elevated left ventricular filling pressure (TZ from 30 to 24 mm Hg; NP from 31 to 20 mm Hg; both P < 0.001). TZ also raised the low cardiac index (CI) of 2.02 to 2.59 l/min/M2 (P < 0.001), whereas NP elevated CI from 2.16 to 2.96 l/min/M2 (P < 0.001). Both drugs lowered (P < 0.05) total systemic vascular resistance and pressure time/minute while enhancing (P < 0.01) stroke work index. The drugs diminished forearm venous tone (P < 0.02) and forearm vascular resistance (P < 0.01) concomitantly with elevation of forearm blood flow (P < 0.05). Thus, TZ induced qualitatively similar marked augmentation of cardiac function to that by NP. These encouraging hemodynamic findings indicate that TZ may be beneficial to patients undergoing ambulatory vasodilator therapy of severe chronic congestive heart failure.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number3
StatePublished - Mar 1982

Fingerprint

Nitroprusside
Myocardial Ischemia
Vasodilator Agents
Forearm
Vascular Resistance
Heart Failure
Hemodynamics
Ventricular Pressure
Pharmaceutical Preparations
trimazosin
Stroke
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cardiocirculatory actions of trimazosin and sodium nitroprusside in ischemic heart disease. / Awan, Najam A.; Hermanovich, John; Vera, Zakauddin; Amsterdam, Ezra A; Mason, Dean T.

In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 3, 03.1982, p. 290-296.

Research output: Contribution to journalArticle

Awan, Najam A. ; Hermanovich, John ; Vera, Zakauddin ; Amsterdam, Ezra A ; Mason, Dean T. / Cardiocirculatory actions of trimazosin and sodium nitroprusside in ischemic heart disease. In: Clinical Pharmacology and Therapeutics. 1982 ; Vol. 31, No. 3. pp. 290-296.
@article{84cf313f97d648beb80bfbd367263786,
title = "Cardiocirculatory actions of trimazosin and sodium nitroprusside in ischemic heart disease",
abstract = "Although postload-reducing drugs are effective vasodilators in chronic congestive heart failure, the clinical application of the approach to ambulatory patient management remains difficult. We compared the hemodynamic effects of the new oral systemic vasodilator trimazosin (TZ) with those of nitroprusside (NP). Both TZ (172 mg) and NP (46 μg/min) decreased mean blood pressure modestly (P < 0.001), while causing considerable decline in elevated left ventricular filling pressure (TZ from 30 to 24 mm Hg; NP from 31 to 20 mm Hg; both P < 0.001). TZ also raised the low cardiac index (CI) of 2.02 to 2.59 l/min/M2 (P < 0.001), whereas NP elevated CI from 2.16 to 2.96 l/min/M2 (P < 0.001). Both drugs lowered (P < 0.05) total systemic vascular resistance and pressure time/minute while enhancing (P < 0.01) stroke work index. The drugs diminished forearm venous tone (P < 0.02) and forearm vascular resistance (P < 0.01) concomitantly with elevation of forearm blood flow (P < 0.05). Thus, TZ induced qualitatively similar marked augmentation of cardiac function to that by NP. These encouraging hemodynamic findings indicate that TZ may be beneficial to patients undergoing ambulatory vasodilator therapy of severe chronic congestive heart failure.",
author = "Awan, {Najam A.} and John Hermanovich and Zakauddin Vera and Amsterdam, {Ezra A} and Mason, {Dean T.}",
year = "1982",
month = "3",
language = "English (US)",
volume = "31",
pages = "290--296",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Cardiocirculatory actions of trimazosin and sodium nitroprusside in ischemic heart disease

AU - Awan, Najam A.

AU - Hermanovich, John

AU - Vera, Zakauddin

AU - Amsterdam, Ezra A

AU - Mason, Dean T.

PY - 1982/3

Y1 - 1982/3

N2 - Although postload-reducing drugs are effective vasodilators in chronic congestive heart failure, the clinical application of the approach to ambulatory patient management remains difficult. We compared the hemodynamic effects of the new oral systemic vasodilator trimazosin (TZ) with those of nitroprusside (NP). Both TZ (172 mg) and NP (46 μg/min) decreased mean blood pressure modestly (P < 0.001), while causing considerable decline in elevated left ventricular filling pressure (TZ from 30 to 24 mm Hg; NP from 31 to 20 mm Hg; both P < 0.001). TZ also raised the low cardiac index (CI) of 2.02 to 2.59 l/min/M2 (P < 0.001), whereas NP elevated CI from 2.16 to 2.96 l/min/M2 (P < 0.001). Both drugs lowered (P < 0.05) total systemic vascular resistance and pressure time/minute while enhancing (P < 0.01) stroke work index. The drugs diminished forearm venous tone (P < 0.02) and forearm vascular resistance (P < 0.01) concomitantly with elevation of forearm blood flow (P < 0.05). Thus, TZ induced qualitatively similar marked augmentation of cardiac function to that by NP. These encouraging hemodynamic findings indicate that TZ may be beneficial to patients undergoing ambulatory vasodilator therapy of severe chronic congestive heart failure.

AB - Although postload-reducing drugs are effective vasodilators in chronic congestive heart failure, the clinical application of the approach to ambulatory patient management remains difficult. We compared the hemodynamic effects of the new oral systemic vasodilator trimazosin (TZ) with those of nitroprusside (NP). Both TZ (172 mg) and NP (46 μg/min) decreased mean blood pressure modestly (P < 0.001), while causing considerable decline in elevated left ventricular filling pressure (TZ from 30 to 24 mm Hg; NP from 31 to 20 mm Hg; both P < 0.001). TZ also raised the low cardiac index (CI) of 2.02 to 2.59 l/min/M2 (P < 0.001), whereas NP elevated CI from 2.16 to 2.96 l/min/M2 (P < 0.001). Both drugs lowered (P < 0.05) total systemic vascular resistance and pressure time/minute while enhancing (P < 0.01) stroke work index. The drugs diminished forearm venous tone (P < 0.02) and forearm vascular resistance (P < 0.01) concomitantly with elevation of forearm blood flow (P < 0.05). Thus, TZ induced qualitatively similar marked augmentation of cardiac function to that by NP. These encouraging hemodynamic findings indicate that TZ may be beneficial to patients undergoing ambulatory vasodilator therapy of severe chronic congestive heart failure.

UR - http://www.scopus.com/inward/record.url?scp=0020039664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020039664&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 290

EP - 296

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 3

ER -