The cardiac-specific contractile proteins, troponin I and T, are highly accurate indicators of myocardial necrosis. Current data support a higher sensitivity and specificity of these markers for detecting cardiac injury than afforded by current methods. The troponins can be measured by simple, rapid, and accurate assays, essential attributes of an effective diagnostic marker. The accuracy of the troponins has been confirmed in large series of patients with Q wave myocardial infarction and other acute coronary syndromes. Diagnostic utility is predicated on two measurements, one of which is obtained at least six hours after the onset of symptoms. In addition, short and long term prognosis of patients presenting with chest pain has been related to the magnitude of elevation of the troponins. The specificity of the troponins for diagnosing myocardial infarction may be limited in low risk populations presenting with chest pain, which could be related to methodological factors as well as detection of nonischemic myocardial damage. At this time, the troponins can be considered an important addition to methods for detecting myocardial injury and they should be utilized as one element in a comprehensive clinical evaluation. (C) 2000 by CVR and R, Inc.
|Original language||English (US)|
|Number of pages||6|
|Journal||Cardiovascular Reviews and Reports|
|State||Published - Jan 2000|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine