Cardiac tamponade in a pediatric renal transplant recipient on sirolimus therapy

Uyen Truong, Anita J. Moon-Grady, Lavjay Butani

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Because of its lack of nephrotoxicity, the use of sirolimus, as an immunosuppressive agent, has increased considerably in solid-organ transplant (Tx) recipients. With its increased use, Tx professionals are encountering a variety of previously unreported side-effects such as angioedema and interstitial pneumonitis. We describe here the case of a pediatric renal Tx recipient who, while receiving sirolimus, developed a large pericardial effusion requiring pericardiocentesis. An extensive workup for an infectious etiology was performed; the only positive result was isolation of adenovirus type 2 from the patient's stool specimen. Following sirolimus dose reduction this child's effusion stabilized and has not recurred. The purpose of this report is to advise health-care professionals caring for Tx recipients about this potentially life-threatening complication associated with sirolimus. The role of adenovirus, if any, in contributing to the development of our patient's pericardial effusion is discussed herein.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalPediatric Transplantation
Volume9
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • Effusion
  • Kidney
  • Pericardial
  • Sirolimus
  • Tamponade
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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