Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Hao Yin; Oula Akawi; Stephanie A. Fox; Fuyan Li; Caroline O'Neil; Brittany Balint; John Michael Arpino; Alanna Watson; Jorge Wong; Linrui Guo; MacKenzie A. Quantz; A. Dave Nagpal; Bob Kiaii; Michael W.A. Chu; J. Geoffrey Pickering

doi:10.1016/j.jacbts.2018.07.004

Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Hao Yin, Oula Akawi, Stephanie A. Fox, Fuyan Li, Caroline O'Neil, Brittany Balint, John Michael Arpino, Alanna Watson, Jorge Wong, Linrui Guo, MacKenzie A. Quantz, A. Dave Nagpal, Bob Kiaii, Michael W.A. Chu, J. Geoffrey Pickering

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.

Original language	English (US)
Pages (from-to)	591-600
Number of pages	10
Journal	JACC: Basic to Translational Science
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/j.jacbts.2018.07.004
State	Published - Oct 2018
Externally published	Yes

Keywords

atrium
risk
surgery
telomere shortening

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2018.07.004

Cite this

Yin, H., Akawi, O., Fox, S. A., Li, F., O'Neil, C., Balint, B., Arpino, J. M., Watson, A., Wong, J., Guo, L., Quantz, M. A., Nagpal, A. D., Kiaii, B., Chu, M. W. A., & Pickering, J. G. (2018). Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery. JACC: Basic to Translational Science, 3(5), 591-600. https://doi.org/10.1016/j.jacbts.2018.07.004

Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery. / Yin, Hao; Akawi, Oula; Fox, Stephanie A.; Li, Fuyan; O'Neil, Caroline; Balint, Brittany; Arpino, John Michael; Watson, Alanna; Wong, Jorge; Guo, Linrui; Quantz, MacKenzie A.; Nagpal, A. Dave; Kiaii, Bob; Chu, Michael W.A.; Pickering, J. Geoffrey.

In: JACC: Basic to Translational Science, Vol. 3, No. 5, 10.2018, p. 591-600.

Research output: Contribution to journal › Article › peer-review

Yin, Hao ; Akawi, Oula ; Fox, Stephanie A. ; Li, Fuyan ; O'Neil, Caroline ; Balint, Brittany ; Arpino, John Michael ; Watson, Alanna ; Wong, Jorge ; Guo, Linrui ; Quantz, MacKenzie A. ; Nagpal, A. Dave ; Kiaii, Bob ; Chu, Michael W.A. ; Pickering, J. Geoffrey. / Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery. In: JACC: Basic to Translational Science. 2018 ; Vol. 3, No. 5. pp. 591-600.

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AB - Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.

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Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Abstract

Keywords

ASJC Scopus subject areas

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