Abstract
Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.
Original language | English (US) |
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Pages (from-to) | 591-600 |
Number of pages | 10 |
Journal | JACC: Basic to Translational Science |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2018 |
Externally published | Yes |
Keywords
- atrium
- risk
- surgery
- telomere shortening
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine