Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Hao Yin, Oula Akawi, Stephanie A. Fox, Fuyan Li, Caroline O'Neil, Brittany Balint, John Michael Arpino, Alanna Watson, Jorge Wong, Linrui Guo, MacKenzie A. Quantz, A. Dave Nagpal, Bob Kiaii, Michael W.A. Chu, J. Geoffrey Pickering

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.

Original languageEnglish (US)
Pages (from-to)591-600
Number of pages10
JournalJACC: Basic to Translational Science
Volume3
Issue number5
DOIs
StatePublished - Oct 2018
Externally publishedYes

Keywords

  • atrium
  • risk
  • surgery
  • telomere shortening

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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