Cardiac Na Channels: Structure to Function

K. R. DeMarco, Colleen E Clancy

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations


Heart rhythms arise from electrical activity generated by precisely timed opening and closing of ion channels in individual cardiac myocytes. Opening of the primary cardiac voltage-gated sodium (NaV1.5) channel initiates cellular depolarization and the propagation of an electrical action potential that promotes coordinated contraction of the heart. The regularity of these contractile waves is critically important since it drives the primary function of the heart: to act as a pump that delivers blood to the brain and vital organs. When electrical activity goes awry during a cardiac arrhythmia, the pump does not function, the brain does not receive oxygenated blood, and death ensues. Perturbations to NaV1.5 may alter the structure, and hence the function, of the ion channel and are associated downstream with a wide variety of cardiac conduction pathologies, such as arrhythmias.

Original languageEnglish (US)
Title of host publicationNa Channels from Phyla to Function, 2016
PublisherAcademic Press Inc.
Number of pages25
ISBN (Print)9780128053867
StatePublished - 2016

Publication series

NameCurrent Topics in Membranes
ISSN (Print)10635823


  • Kinetic processes
  • Na channel
  • Na1.5
  • SCN5A
  • Structure and function

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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