Cardiac Excitation-Contraction Coupling

Donald M Bers, S. Despa

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Contraction of the heart, required to pump the blood out of the left ventricle, is a complex process that involves electrical excitation of the cardiac muscle, finely tuned changes in the intracellular concentration of the ubiquitous second-messenger calcium (Ca), and activation of the contractile apparatus of cardiac myocytes. This process is called 'excitation-contraction (E-C) coupling'. The electrical impulse generated by the cardiac pacemaker cells propagates to the ventricle where it triggers cardiac myocyte depolarization. Depolarization opens voltage-dependent Ca channels, allowing Ca to enter cardiac myocytes and trigger Ca release from the sarcoplasmic reticulum. The combination of Ca entry and Ca release raises the intracellular Ca concentration, allowing Ca to bind to the myofilaments and activate contraction. Relaxation occurs when Ca is extruded from the cytosol. Defective E-C coupling leads to heart failure (HF), a syndrome that develops when the amount of blood pumped from the heart is inadequate to meet the metabolic demands of the body. HF is characterized by both contractile dysfunction and increased propensity for fatal arrhythmias. In this article, we review the E-C coupling process in healthy hearts and the main alterations that lead to reduced contractions and arrhythmias in HF.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages379-383
Number of pages5
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Fingerprint

Excitation Contraction Coupling
Calcium
Cardiac Myocytes
Heart Failure
Depolarization
Cardiac Arrhythmias
Blood
Pacemakers
Myofibrils
Sarcoplasmic Reticulum
Second Messenger Systems
Calcium Channels
Cytosol
Heart Ventricles
Muscle
Myocardium
Chemical activation
Pumps

Keywords

  • Action potential
  • Arrhythmias
  • Contraction
  • Heart failure
  • Intracellular Ca
  • Ryanodine receptors
  • Sarcoplasmic reticulum
  • Sodium/calcium exchanger

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bers, D. M., & Despa, S. (2013). Cardiac Excitation-Contraction Coupling. In Encyclopedia of Biological Chemistry: Second Edition (pp. 379-383). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00221-8

Cardiac Excitation-Contraction Coupling. / Bers, Donald M; Despa, S.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 379-383.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bers, DM & Despa, S 2013, Cardiac Excitation-Contraction Coupling. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 379-383. https://doi.org/10.1016/B978-0-12-378630-2.00221-8
Bers DM, Despa S. Cardiac Excitation-Contraction Coupling. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 379-383 https://doi.org/10.1016/B978-0-12-378630-2.00221-8
Bers, Donald M ; Despa, S. / Cardiac Excitation-Contraction Coupling. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 379-383
@inbook{db4ee09d07ee40ccba27424d8be600dd,
title = "Cardiac Excitation-Contraction Coupling",
abstract = "Contraction of the heart, required to pump the blood out of the left ventricle, is a complex process that involves electrical excitation of the cardiac muscle, finely tuned changes in the intracellular concentration of the ubiquitous second-messenger calcium (Ca), and activation of the contractile apparatus of cardiac myocytes. This process is called 'excitation-contraction (E-C) coupling'. The electrical impulse generated by the cardiac pacemaker cells propagates to the ventricle where it triggers cardiac myocyte depolarization. Depolarization opens voltage-dependent Ca channels, allowing Ca to enter cardiac myocytes and trigger Ca release from the sarcoplasmic reticulum. The combination of Ca entry and Ca release raises the intracellular Ca concentration, allowing Ca to bind to the myofilaments and activate contraction. Relaxation occurs when Ca is extruded from the cytosol. Defective E-C coupling leads to heart failure (HF), a syndrome that develops when the amount of blood pumped from the heart is inadequate to meet the metabolic demands of the body. HF is characterized by both contractile dysfunction and increased propensity for fatal arrhythmias. In this article, we review the E-C coupling process in healthy hearts and the main alterations that lead to reduced contractions and arrhythmias in HF.",
keywords = "Action potential, Arrhythmias, Contraction, Heart failure, Intracellular Ca, Ryanodine receptors, Sarcoplasmic reticulum, Sodium/calcium exchanger",
author = "Bers, {Donald M} and S. Despa",
year = "2013",
month = "2",
day = "15",
doi = "10.1016/B978-0-12-378630-2.00221-8",
language = "English (US)",
isbn = "9780123786302",
pages = "379--383",
booktitle = "Encyclopedia of Biological Chemistry",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Cardiac Excitation-Contraction Coupling

AU - Bers, Donald M

AU - Despa, S.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Contraction of the heart, required to pump the blood out of the left ventricle, is a complex process that involves electrical excitation of the cardiac muscle, finely tuned changes in the intracellular concentration of the ubiquitous second-messenger calcium (Ca), and activation of the contractile apparatus of cardiac myocytes. This process is called 'excitation-contraction (E-C) coupling'. The electrical impulse generated by the cardiac pacemaker cells propagates to the ventricle where it triggers cardiac myocyte depolarization. Depolarization opens voltage-dependent Ca channels, allowing Ca to enter cardiac myocytes and trigger Ca release from the sarcoplasmic reticulum. The combination of Ca entry and Ca release raises the intracellular Ca concentration, allowing Ca to bind to the myofilaments and activate contraction. Relaxation occurs when Ca is extruded from the cytosol. Defective E-C coupling leads to heart failure (HF), a syndrome that develops when the amount of blood pumped from the heart is inadequate to meet the metabolic demands of the body. HF is characterized by both contractile dysfunction and increased propensity for fatal arrhythmias. In this article, we review the E-C coupling process in healthy hearts and the main alterations that lead to reduced contractions and arrhythmias in HF.

AB - Contraction of the heart, required to pump the blood out of the left ventricle, is a complex process that involves electrical excitation of the cardiac muscle, finely tuned changes in the intracellular concentration of the ubiquitous second-messenger calcium (Ca), and activation of the contractile apparatus of cardiac myocytes. This process is called 'excitation-contraction (E-C) coupling'. The electrical impulse generated by the cardiac pacemaker cells propagates to the ventricle where it triggers cardiac myocyte depolarization. Depolarization opens voltage-dependent Ca channels, allowing Ca to enter cardiac myocytes and trigger Ca release from the sarcoplasmic reticulum. The combination of Ca entry and Ca release raises the intracellular Ca concentration, allowing Ca to bind to the myofilaments and activate contraction. Relaxation occurs when Ca is extruded from the cytosol. Defective E-C coupling leads to heart failure (HF), a syndrome that develops when the amount of blood pumped from the heart is inadequate to meet the metabolic demands of the body. HF is characterized by both contractile dysfunction and increased propensity for fatal arrhythmias. In this article, we review the E-C coupling process in healthy hearts and the main alterations that lead to reduced contractions and arrhythmias in HF.

KW - Action potential

KW - Arrhythmias

KW - Contraction

KW - Heart failure

KW - Intracellular Ca

KW - Ryanodine receptors

KW - Sarcoplasmic reticulum

KW - Sodium/calcium exchanger

UR - http://www.scopus.com/inward/record.url?scp=85042757040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042757040&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-378630-2.00221-8

DO - 10.1016/B978-0-12-378630-2.00221-8

M3 - Chapter

AN - SCOPUS:85042757040

SN - 9780123786302

SP - 379

EP - 383

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Inc.

ER -