Cardiac excitation-contraction coupling

Research output: Contribution to journalArticle

2576 Citations (Scopus)

Abstract

Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation-contraction coupling. It is important to understand in quantitative detail exactly how calcium is moved around the various organelles of the myocyte in order to bring about excitation-contraction coupling if we are to understand the basic physiology of heart function. Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalNature
Volume415
Issue number6868
DOIs
StatePublished - Jan 10 2002
Externally publishedYes

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Excitation Contraction Coupling
Calcium
Organelles
Muscle Cells
Ions

ASJC Scopus subject areas

  • General

Cite this

Cardiac excitation-contraction coupling. / Bers, Donald M.

In: Nature, Vol. 415, No. 6868, 10.01.2002, p. 198-205.

Research output: Contribution to journalArticle

Bers, Donald M. / Cardiac excitation-contraction coupling. In: Nature. 2002 ; Vol. 415, No. 6868. pp. 198-205.
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